2010–2014年我院935例药品不良反应报告分析

Analysis of 935 ADR reports in our hospital from 2010 to 2014

目的：了解我院药品不良反应（ADR）的发生规律及特点,总结经验以促进患者用药安全、有效。方法：采用回顾性分析方法,收集我院2010–2014年共计935例ADR监测报告,对患者性别、年龄、药品种类、给药途径、累及系统/器官及主要临床表现、转归等进行分析。结果：我院ADR报告的数量、质量逐步提高,935例报告中新的及严重的ADR 110例（11.76%）,其中严重的ADR 36例（3.85%）;男性患者436例（46.63%）,女性患者499例（53.37%）,21~50岁患者构成比（49.63%）最高;主要累及的系统/器官为皮肤及附件（43.84%）;引起ADR频次最高的药物为抗感染药物（40.64%）,给药途径中以静脉给药的构成比最高（78.50%）。结论：我院ADR监测工作在以患者为中心的基础上,监管部门高度重视,多措并举,特别是鼓励全体药师积极参与之后,该工作水平逐步提高,促进了患者用药的安全、有效。

Objective： To analyze and sum up the experience of adverse drug reaction（ADR） monitoring in our hospital, and promote the patient’s medication safety and effectiveness. Methods： A total of 935 ADR reports in our hospital from 2010 to 2014 were collected retrospectively. The data in respect of age and gender of patients, categories of drugs, route of administration, systems and organs involved in ADR, clinical manifestations and prognosis were analyzed statistically. Results： The quantity and quality of ADR reports in our hospital improved gradually. Among 935 ADR reports, there were 110 cases（11.76%） of new and severe ADR, and 36 cases（3.85%） were severe ADR; 436 cases（46.63%） were male and 499 cases（53.37%） were female; patients aged from 21 to 50 years accounted for the largest proportion（49.63%）; skin and appendages damage was the most frequent ADR（43.84%）; the most frequency in suspected drugs was anti-infective drugs（40.64%）; the main administration route causing ADR was intravenous administration（78.50%）. Conclusion： On the basis of the concept of ＂patient-centered services＂ and attention of leadership, the work of ADR monitoring was advancing all the time by taking several measures, such as encouraging the participation of all the pharmacists, for promoting patient’s medication safety and effectiveness.