不同方法治疗乳腺增生症的临床疗效分析

Comparative effectiveness research on clinical efficacy of different therapies in the treatment of mammary gland hyperplasia

目的比较药物保守治疗与乳管镜冲洗法治疗乳腺增生症的临床疗效。方法选择2011年12月至2013年12月鄂州市中心医院收治的90例乳腺增生症患者为研究对象,按照随机数字表法,将其分为A组（n=45,采用乳管镜冲洗法治疗）和B组（n=45,采用药物保守治疗）。比较两组患者的临床疗效、治疗前及治疗后乳房肿块直径及乳房疼痛程度评分、不良反应发生率等。两组患者的年龄、病程、肿块部位、肿块直径等一般临床病历资料比较,差异均无统计学意义（P〉0.05）。本研究遵循的程序符合鄂州市中心医院人体试验委员会制定的伦理学标准,得到该委员会批准。结果 1A组患者的痊愈率、有效率均高于B组,并且A组患者的总有效率显著高于B组（93.3%vs 73.3%）,差异有统计学意义（χ^2=5.916,P〈0.05）。2A组、B组患者治疗前、后乳房肿块直径、乳房疼痛程度分别比较[A组：（2.6±0.4）cmvs（1.0±0.3）cm,（3.0±0.5）分vs（0.9±0.2）分;B组：（2.6±0.4）cmvs（1.8±0.3）cm;（3.0±0.5）分vs（1.5±0.3）分],差异均有统计学意义（A组：t=8.273,9.173;P〈0.05;B组：t=3.342,4.196;P〈0.05）;治疗后A组患者乳房肿块直径、乳房疼痛评分明显低于B组,并且差异有统计学意义（t=3.029,3.522;P〈0.05）。3两组患者总体不良反应发生率比较（15.6%vs 17.8%）,差异无统计学意义（χ^2=0.080,P〉0.05）。结论乳管镜冲洗法治疗乳腺增生症能明显改善患者临床症状,提高治疗效果。

Objective To compare the clinical effectiveness of conservative therapy treatment and breast duct endoscope flushing in the treatment of mammary gland hyperplasia.Methods From December 2011 to December 2013,a total of 90 patients with mammary gland hyperplasia were treated as the research objects.They were divided into group A（n=45,received breast duct endoscope flushing）and group B（n=45,received drug therapy）by random number table.The clinical efficacy,breast tumor diameters and breast pain degree score,the incidence of adverse reactions were compared between two groups.There were no statistically significant difference between two groups in the aspect of age,course of disease,the location of the mammary mass,the diameter of the mammary mass and the other clinical records（P〉0.05）.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Ezhou Central Hospital.Results 1 The recovery rate and efficacy rate of patients of group A were higher than those of group B,and the total effective rate of group A was significantly higher than that of group B（93.3% vs73.3%）,the difference had statistical significance（χ^2=5.916,P〈0.05）.2 The mammary mass diameters and breast pain degrees of group A and group B before and after the treatment were respectively compared[group A：（2.6±0.4）cmvs（1.0±0.3）cm,（3.0±0.5）score vs（0.9±0.2）score;group B：（2.6±0.4）cmvs（1.8±0.3）cm;（3.0±0.5）score vs（1.5±0.3）score],the difference had statistical significance（group A：t=8.273,9.173,P0.05;group B：t=3.342,4.196,P〈0.05）.After the treatment,the breast lumps diameter and breast pain score of group A were significantly lower than those of group B,and the difference was statistically significant（t=3.029,3.522,P〈0.05）.3There was no statistically significant difference between two groups in the aspect of total adverse reaction（15.6% vs17.8%;χ^2=0.080,P〉0.05）.Conclusions Breast duct endoscope flushing in the treatment of mammary gland hyperplasia can obviously improve the clinical symptoms and treatment effects.