膳食纤维抗癌作用及其分子机理的研究进展

A Review on Anticancer Function of Dietary Fiber and the Molecular Mechanism

综述了膳食纤维流行病学和动物实验方面的抗癌证据,以及膳食纤维的量与不同类型癌症发生率的关系,分析了膳食纤维通过排毒、消炎、肠道菌群和脂代谢的调控参与抗癌的机理;在分子细胞水平,总结了膳食纤维对癌细胞周期阻滞和促使癌细胞凋亡的分子机理,以及其对癌变信号通路的调控。近年来的研究发现,膳食纤维具有抗肥胖、抗心脑血管疾病、消炎和抗糖尿病等生理功能,已成为维系人类身体健康、不能被其它物质所替代的一种营养素,被誉为人体的"第七营养素"。本文将为深入研究膳食纤维的抗癌分子机理和进一步开发膳食纤维功能性食品提供参考。

Dietary fiber,known as ＂the seventh nutrient＂ of the body,is a particular nutrient to maintain health,which cannot be replaced by other substances. Recent studies have found that dietary fiber contributes to anti-obesity,anti-inflammation,anti-diabetes and anti-cardiovascular diseases. This paper summarizes anticancer evidences of the dietary fiber in epidemiological and animal experiments,and analyzes the relationship between anticancer effects and the amounts of dietary fiber. Dietary fiber can inhibit carcinogenesis through detoxification,anti-inflammation and the regulations of intestinal microflora and lipid and steroids metabolism. From molecular and cellular levels,we summarize that dietary fiber can arrest the cell cycle,promote apoptosis of cancer cells and regulate the signal transduction pathways of carcinogenesis. This paper provides references for further investigation into anti-cancer molecular mechanisms of dietary fiber and development of dietary fiber-based functional foods.