帕金森老年患者的认知功能损伤状况研究

Investigation on cognitive impairment of elder Parkinson patients

目的探讨老年帕金森病患者认知功能损伤状况,分析老年帕金森患者认知功能损伤的特点。方法将2013年7月至2014年12月间就诊于我院的193例老年帕金森病患者分为帕金森伴发认知功能损伤(PD-CI)组和帕金森病认知功能正常(PD-NCI)组,应用蒙特利尔认知评估量表(Mo CA)、帕金森病生活质量问卷(PDQ-39)及汉密尔顿抑郁量表(HAMD)等对患者的非运动症状进行诊断和评估。结果 PD-CI组7项Mo CA评分均显著低于PD-NCI组(P<0.05)。PD-NCI组病程[(3.15±2.98)年]显著性短于PD-CI组[(4.52±3.41)年](P<0.05),而受教育程度PD-NCI组显著高于PD-CI组(P<0.05)。PD-CI组生存质量得分(132.73±12.41)显著低于PD-NCI组(144.53±11.89)(P<0.05)。生活自理能力PD-NCI组(47.14±4.22)优于PD-CI组(38.67±3.62)(P<0.05)。PD-CI组抑郁率为82.65%,PD-NCI组为54.74%;PD-CI组抑郁等级显著高于PD-NCI组(U=19.430,P<0.05)。结论认知功能障碍对患者生活影响大,应对其充分研究并制定相应的医疗措施有利于提高患者生存质量。

Objective To investigate the cognitive impairment (CI) of elder Parkinson patients and analyze the features of elder Parkinson patients with CI. Methods From July 2013 to December 2014 in our hospital, 193 cases of PD patients were selected and randomly divided into PD with cognitive impairment (PD-CI) group and PD with no cognitive impairment (PD-NCI) group. Diagnosed and evaluated the non motor symptoms (NMS) by The Montreal Cognitive Assessment (MoCA), PD Quality-39 (PDQ-39) and Hamilton Depression Scale (HAMD). Results The MoCA scores of PD-CI group were significantly lower than that of PD-NCI group (P<0.05). The PD-NCI group (3.15±2.98) years was short than PD-CI (4.52±3.41) years in course of disease (P<0.05), and the education level of PD-NCI was significantly higher than PD-CI (P<0.05). The life quality of PD-CI (132.73±12.41) was significantly lower than PD-NCI (144.53±11.89) (P<0.05). Ability of daily living, PD-NCI (47.14±4.22) was better than PD-CI (38.67±3.62) (P<0.05). Depression rate of PD-CI group was 82.65% and 54.74% for PD-NCI. The depression rate of PD-CI was significantly higher than PD-NCI (U=19.430, P<0.05). Conclusion Cognitive impairment is great obstacle of normal life for PDs, it’s valuable for improving the life quality of PDs to study CI and make corresponding therapy.