肺鳞癌中Furin和E-cadherin的表达研究

Study on expressions of Furin and E-cadherin in lung squamous cell carcinoma

目的检测肺鳞癌中弗林蛋白酶(Furin)和上皮型黏附素(E-cadherin)的表达,分析二者在不同临床特征中的表达差别,关注其临床意义。方法选择65例肺鳞癌作为观察组,选择50例正常肺组织作为对照组,应用免疫组化方法检测Furin和E-cadherin的表达,统计学分析应用卡方检验或相关性分析。结果观察组中Furin表达的阳性率明显高于对照组(53.85%vs.4.00%,P<0.000 1),观察组中E-cadherin表达的阳性率明显低于对照组(16.92%vs.98.00%,P<0.000 1)。观察组中Furin和E-cadherin的表达均与肿瘤的最大径、分化程度和脉管浸润密切相关(P<0.05)。察组中Furin和E-cadherin的表达无相关性(P>0.05)。结论肺鳞癌中Furin高表达、E-cadherin低表达是促进肿瘤发生和进展的重要因素,Furin和E-cadherin无明显的协同作用。

Objective To detect the expressions of Furin and E-cadherin in lung squamous cell carcinoma, analyze the clinical significance. Methods The observation group included 65 cases with lung squamous cell carcinoma, the control group included 50 cases with normal lung tissue. Expressions of Furin and E-cadherin were detected by IHC. Chi-square test and correlation analysis were used in study. Results The expression of Furin was higher in the observation group than in the control group(53.85% vs. 4.00%, P<0.000 1). The expression of E-cadherin was lower in the observation group than in the control group(16.92% vs. 98.00%, P<0.000 1). Expressions of Furin and E-cadherin were associated with diameter, differentiation and vascular invasion(P<0.05). The expressions of Furin and E-cadherin were not correlated in observation group(P>0.05). Conclusion The higher expression of Furin, lower of E-cadherin may promote the occurrence and development of lung squamous cell carcinoma. The expressions of Furin and E-cadherin are not obvious synergistic effect in observation group.