摘要
NLRP3炎性小体是炎性免疫反应的重要组成部分,它能够识别内源性危险信号,激活caspase-1,继而活化白细胞介素IL-1β和IL-18等细胞因子,参与诸多慢性疾病体内非感染性炎性反应。本文拟对NLRP3炎性小体与慢性炎性疾病2型糖尿病及冠心病并发症的关系作一综述。
NLRP3 inflammasome is indicated as an important component of the inflammatory immune response, it can identify endogenous danger signals, lead to the activation of caspase-1 and then activate cytokines interleukin(IL)-1β, IL-18, and play an important role in inflammatory processes of chronic non-infectious diseases in vivo. Here we discussed the advance in the role of NLRP3 inflammasome in chronic inflammatory diseases such as type 2 diabetes and diabetic coronary heart disease.
出处
《中华临床医师杂志（电子版）》
CAS
2015年第23期136-139,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
重庆涪陵区科技计划项目(FLKJ
2014ABB2104)
重庆市卫生和计划生育委员会科研计划项目(2015MSXM138)
关键词
糖尿病
2型
冠心病
炎性小体
炎性反应
Diabetes mellitus,type 2
Coronary heart disease
Inflammasome
Inflammation
