阿托伐他汀钙片治疗卒中后认知功能障碍患者的综合疗效

The Comprehensive Effect of Cognitive Dysfunction in Patients with Atorvastatin Calcium Tablets therapy after Stroke

目的探讨阿托伐他汀钙片治疗卒中后认知功能障碍患者的综合疗效。方法选取2014年6月至2015年6月沈阳市第一人民医院收治的69例卒中后认知功能障碍患者为研究对象,按随机数字表法将其分为观察组(39例)和对照组(30例)。对照组患者给予常规药物治疗,观察组患者在对照组基础上口服阿托伐他汀钙片,比较两组患者治疗前后简易精神状态量表(MMSE)评分、日常生活能力量表(ADL)评分、临床疗效及不良反应发生情况。结果治疗后,观察组患者的MMSE评分明显高于对照组,ADL评分明显低于对照组,差异均有统计学意义(均P<0.05);观察组患者的总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论阿托伐他汀钙片治疗卒中后认知功能障碍患者临床疗效明显,可明显改善患者的认知功能和生活能力,且安全性较高。

Objective To investigate the Atorvastatin Calcium Tablets effects on cognitive impairment in patients with stroke.Methods From June 2014 to June 2015,69 patients with cognitive dysfunction after stroke were randomly divided into observation group（39 cases） and control group（30 cases） by random number table method.The control group were given routine drug treatment were observed patients in the control group based on oral atorvastatin calcium tablets,were compared between the two groups before and after treatment in patients with mini mental state table（MMSE） score,daily life ability scale（ADL） score,clinical efficacy and adverse reactions of hair.Results After the treatment,the MMSE score of the observation group was significantly higher than that of the control group,the ADL score was significantly lower than the control group,the difference was statistically significant（P〈0.05）;the total effective rate in the observation group was significantly higher than that in the control group,the difference was statistically significant（P〈0.05）.Conclusion Atorvastatin calcium tablets in the treatment of stroke cognitive dysfunction in patients with clinical curative effect is obvious,can significantly improve patients cognitive function and activities of daily living,and the safety is high.