不同寒热药性海洋中药在海洋生物系统发育树的分布规律及其关联关系分析

The Distribution and Association Relationships of Marine Chinese Medicine with Different Nature in the Phylogenetic Tree of Marine Organisms

目的:海洋中药是我国中药资源宝库的重要组成部分,海洋生物资源的开发为海洋中药的发展奠定了基础,如何快速客观评价海洋中药新资源的药性已成为制约海洋中药发展和临床应用的主要瓶颈问题之一。方法:本文以613味海洋中药涉及的1 091种海洋中药物种为研究对象,采用关联规则挖掘(Association Rules Mining)和系统发育树(Phylogenetic Tree)构建方法,分析不同寒热药性海洋中药在海洋生物系统发育树上的分布规律及其关联关系。结果:不同药性的海洋中药在发育树上的分布具有很高的聚集性,来源于相同科物种的海洋中药,其药性基本也一样,很多与同一药性关联程度高的规则分布在系统发育树的同一分支中,或者在发育树上的距离非常近,如与寒性关联程度比较高的绿藻门(Chlorophyta)、红藻纲(Florideophyceae)、褐藻纲(Phaeohpyceae)等海洋植物,与热性关联程度较高的十足目(Decapoda)、软甲纲(Malacostraca)、节肢动物门(Arthropoda)等海洋动物,和平性海洋中药相关程度较高的有鳞目(Squamata)海洋鱼类。结论:以上结果提示药性和海洋生物的门纲科属等亲缘关系信息具有一定的关联关系,来源于亲缘关系相同或相近海洋生物物种的海洋中药可能会具有相同或相近的中药药性,这为海洋中药新资源的药性预测和评价提供了新的评价指标和参考依据。

Marine Chinese Medicine（MCM） is one of the important part of the traditional Chinese medicine. The exploration of marine organism resources provide a good base for the development of MCM. However, the evaluation for the nature of the new source of MCM becomes one of the key problem of the clinic application of MCM. In this study, 613 MCM and their related 1 091 species of marine organisms were screened. Association Rules Mining method and Phylogenetic Tree constructing method were used to find out the association relationship and the distribution regularity of the MCM with different nature in the Phylogenetic Tree. The results showed high collection of the MCM with the same nature on the tree. The MCM from the organisms in the same family might have the same nature. And the association rules for the same nature assembled at the same branch or near branch of the tree. For example, the marine plantae, Chlorophyta, Florideophyceae, and Phaeohpyceae, were related with cold nature, while the marine animalia, including Decapoda, Malacostraca, and Arthropoda, had close relationship with hot nature. Moreover, the neutral nature was related with Squamata. These results implied that there were close relationship between the nature and the affinity relationship. The MCM from the same or close families may have the same or likely nature. This study provided a new index and reference for prediction and evaluation of the nature of new MCM.