四川大学4068例在职职工甲状腺结节患病情况调查

Prevalence of Thyroid Nodules among 4068 Staff Members of Sichuan University

目的了解四川大学在职职工甲状腺结节的患病情况。方法对2013年10月至2014年8月于四川大学华西保健医院健康管理中心体检的既往无甲状腺结节病史的4 068名四川大学在职职工的临床资料、高分辨率甲状腺B超和促甲状腺激素(TSH)测定结果等进行回顾性分析。结果四川大学在职职工甲状腺结节的患病率为24.34%,且随着年龄增加,患病率呈增加趋势(Z=7.53,P=0.031);女职工甲状腺结节患病率(29.46%)高于男职工(19.64%)(2=23.21,P=0.025),且这一趋势在各年龄组均一致。同时,657例接受TSH水平测定的甲状腺结节患者中,TSH水平异常者占12.33%,多发结节组和单发结节组TSH水平接近,差异无统计学意义(P=0.210)。结论甲状腺结节在四川大学在职职工中患病率较高,随年龄增长发病呈增加趋势,女职工发病率高于男职工,提示随着年龄增长女性体检更应关注甲状腺健康。

Objective To investigate the prevalence of thyroid nodules among staff members of Sichuan University.Methods A total of 4 068 staff members without a past history of thyroid disease were selected from October 2013 to April 2014 during their health examination in our hospital.Retrospective analysis was conducted on their clinical data,high-resolution ultrasonography and serum TSH.Results The incidence rate of thyroid nodules among the staff members were 24.34% and showed an growing trend with age（Z=7.53,P =0.031）.The prevalence was higher in female staffs（29.46%）compared with their male counterparts（19.64%）（X^2=23.21,P=0.025）which was shown in all age groups.Among the 657 cases taken the test of serum TSH,12.33%showed a raised serum TSH level and there was no statistically significant difference between the multiple nodules group and solitary nodule group（P=0.210）.Conclusion The prevalence of thyroid nodules is high among staff members of Sichuan University and the incidence grows with age.Also,thyroid nodules attacks females more often than males.Therefore,females should pay more attention to thyroid health as they grow older.