恩替卡韦与阿德福韦酯治疗乙肝的疗效对比研究

Comparative Effectiveness Research of Entecavir and Adefovir Dipivoxil Treating Hepatitis B

目的：对比恩替卡韦与阿德福韦酯治疗慢性乙型肝炎的疗效。方法：90例慢性乙肝患者平分为恩替卡韦组和阿德福韦酯组，分别采用恩替卡韦和阿德福韦酯治疗，测定两组患者HBV DNA转阴率和ALT复常率。结果：恩替卡韦组HBV DNA转阴率及ALT复常率均显著高于阿德福韦酯组（P〈0.05）。结论：恩替卡韦治疗慢性乙型肝炎的疗效更好。

Objective：To compare the efficacy of entecavir and adefovir dipivoxil treating chronic hepatitis B. Methods：90 patients with chronic hep-atitis B were equally divided into group entecavir and adefovir dipivoxil, respectively treated with entecavir and adefovir dipivoxil, and HBV DNA negative rate and ALT normalizing rate of the two groups were tested. Results：The HBV DNA negative rate and ALT normalizing rate of group ente-cavir were both significantly higher than those of group adefovir dipivoxil （P〈0.05）. Conclusion：The efficacy of entecavir treating chronic hepatitis B is better.