电针刺激治疗缺血性脑卒中患者的大脑局部一致性研究

Effects of acupuncture on brain regional homogeneity at resting state in the patients with ischemic stroke

目的以缺血性脑卒中患者为研究对象,从脑局部一致性(ReH o)的角度揭示针刺治疗缺血性脑卒中的中枢机制,为针刺治疗缺血性脑卒中的临床应用提供科学的可视化依据。方法采用BOLD-fM RI成像技术,以9例缺血性脑卒中患者为研究对象,进行针刺治疗,比较脑卒中患者治疗前后ReH o的异同。结果针刺前、电针头穴、静留针时比较多个脑功能区ReH o存在差异;治疗后基底节区、脑初级运动区、运动前区、辅助运动区、顶下小叶等区域ReH o发生动态变化。结论静息状态下缺血性脑卒中患者存在脑功能区异常,基底节区是缺血性脑卒中患者运动功能损害的主要脑区;脑初级运动区、运动前区、辅助运动区、顶下小叶是脑卒中患者静息态脑功能重组及代偿的关键区域,是针刺治疗脑卒中患者重要的调制区域。

Objective To explore the central mechanisms of acupuncture used to treat ischemic stroke with the regional homogeneity. Methods BOLD-fM RI technology was used in this study. Nine patients with ischemic stroke were chosen as participants. The dynamic change of regional homogeneity of the whole brain was observed before and after treatment. Results Before treatment,at the time of acupuncture or during retaining the needle,the abnormal regional homogeneity occurred in many encephalic regions. After treatment,regional homogeneity signal changed obviously in basal ganglia area（ BGA）,primary motor area（ PMA）,premotor area（ PA）,supplementary motor area（ SMA） and inferior partial lobe（ IPL）. Conclusions Abnormality of regional homogeneity in the resting state occurrs in many encephalic regions of patients with ischemic stroke,and BGA is the main encephalic region which results in motor function injuries;PMA,PA,SMA and IPL are the critical regions for patients with ischemic stroke to accomplish reorganization and compensation of the brain function in the resting state,which are the important areas for acupuncture treating with ischemic stroke.