帕罗西汀联合喹硫平治疗抑郁症的疗效观察

Efficacy of Paroxetine and Quetiapine in the Treatment of Depression

目的探讨帕罗西汀联合奎硫平治疗抑郁症的临床疗效。方法 60例抑郁症患者,根据随机数字法分为对照组(奎硫平)和观察组(对照组基础上,加用帕罗西汀),观察和比较两组治疗前后抑郁及生活质量改善情况,同时监测和比较治疗期间两组不良反应。结果与对照组相比,观察组治疗后汉密顿抑郁量表(hamilton depression scale,HAMD)评分明显降低,差异有统计学意义(t=5.17,P<0.05);与对照组相比,观察组治疗后生活指数评分指数(quality of life index,QLI)评分明显升高,差异有统计学意义(t=5.09,P<0.05);治疗期间两组都没有出现严重的不良反应。结论帕罗西汀联合奎硫平治疗能够明显降低抑郁症患者的抑郁程度,提高其生活质量,并且不良反应少、安全性高,值得临床广泛推广。

Objective To investigate the effect of paroxetine and quetiapine in the treatment of depression. Methods A total of 60 patients with depression were randomly divided into the control group（ quetiapine） and the observation group（ paroxetine and quetiapine）. Life quality,the efficacy of depression and the adverse reactions in the two groups were observed and compared before and after treatment. Results In observation group,the Hamilton depression scale（ HAMD） scores was decreased after the treatment compared with the control group and with statistic difference（ t = 5. 17,P〈0. 05）. Meanwhile,the quality of life index（ QLI） scores was increased and with statistical difference（ t = 5. 09,P〈0. 05）. There was no severe adverse reaction reported. Conclusion Paroxetine and quetiapine in the treatment of depression can significantly reduce the patients＇ depression degree,improve the life quality and with less adverse reactions and more safety. Therefore,it is worthy to clinical promotion.