晚期肾癌靶向治疗的作用机制 耐药机制与对策

Mechanisms of action, resistance, and countermeasures of targeted therapy in advanced renal cell carcinoma

随着对肾癌发生、发展过程中分子调控机制研究的不断深入,以分子信号通路中的关键蛋白酶/蛋白作为靶点开发靶向药物,较好地改善了晚期肾癌患者的治疗现状。但是靶向药物在治疗过程中常出现耐药,从而导致治疗效果降低。本文将对肾癌靶向治疗的作用机制、耐药机制与对策作简要综述。

With the increasingly deepening research on the molecular regulatory mechanisms during the development and progression of advanced renal cell carcinoma, the targeted therapy directed on the key proteinase/protein in the molecular signaling pathways significantly improves the management outcomes. However, the occurring resistance during therapy with targeted agents leads to decreasing effects. The mechanisms of action, resistance, and countermeasures of targeted therapy in advanced renal cell carcinoma are simply reviewed.