结直肠癌患者血清白介素-11、白介素-13和癌胚抗原的表达及相关性

Expressions of IL-11, IL-13 and CEA in patients with colorectal cancer and theircorrelations

目的:探讨结直肠癌患者在根治性手术后血清中IL-11、IL-13和CEA表达水平的差异,并对其进行相关性分析。方法:选取2012年1月至2015年2月本院收治的70例经手术治疗的结直肠癌患者,在术前、术后第2、4、7天采集血液标本;选取在本院进行体检的健康人群25例采集血液标本。记录性别、年龄以及肿瘤大小、肿瘤分期(TNM)等资料,将收集的各组患者血液标本取血清部分,检测IL-11、IL-13和CEA表达水平并记录分析。结果 :结直肠癌患者以男性居多,平均年龄较大,TNM分期Ⅱ、Ⅲ期居多。结直肠癌患者术前血清IL-11、IL-13和CEA表达均较对照组明显升高(P<0.05),而且三者之间具有显著正相关性(P<0.05);经结直肠癌根治术治疗后,未经放化疗,患者血清IL-11、IL-13和CEA表达明显下降,具有明显正相关性(P<0.05)。结论 :结直肠癌根治性手术可降低患者血清中IL-11、IL-13和CEA的表达,三者相互之间具有显著正相关性,与结直肠癌的发生、发展密切相关。

Objective To explore the expressions of IL-11 IL-13 and CEA in patients with colorectal cancer after radical surgery and their correlations Methods Seventy patients with surgical treatment for colorectal cancer （experiment group） were selected from January 2012 to February 2015 for their information of gender, sex, tumor size and tumor stage （TNM） and their blood was collected before the surgery, and in the 2nd, 4th, 7th day after surgery. Twenty-fivd healthy controls were selected as control group randomly. IL-11 IL- 13 and CEA in serum of patients in both groups were tested and analyzed. Results Colorectal cancer most frequently occurred in male patients, averagely with old age, and with phase II and III in the majority of TNM stage. The preoperative expression of IL-11, IL-13 and CEA of patients with colorectal cancer increased significantly than that in control group （P 〈 0.05）; there are positive correlation among them （P 〈 0.05）; the expression of IL-11, IL-13 and CEA decreased significantly after the operation in experiment group, but were still higher than that of control group （P〈 0.05）. Conclusion The expressions of IL-11, IL-13 and CEA decrease significantly after radical surgery, and they are positively correlated, which indicates a close relationship in tumorigenesis and development of colorectal cancer.