薄壁囊腔为影像学特点的继发性淋巴细胞性间质性肺炎2例并文献复习

Two case reports and literature review of secondary lymphoid interstitial pneumonia characterized by thin- walled cystic cavity in imageology

目的通过分析继发性淋巴细胞性间质性肺炎（1ymphoid interstitial pneumonia，LIP）的临床、影像、病理特征，探讨LIP的发病机制，诊断和治疗方法。方法回顾性分析我院确诊的2例LIP患者的临床特点、胸部CT、病理资料，并文献复习加以总结。结果2例患者均为干燥综合征继发淋巴细胞性间质性肺炎；LIP起病缓慢，主要表现为进行性胸闷、呼吸困难；胸部CT均为双肺弥漫性分布的薄壁囊腔，伴有结节影；病理表现为淋巴细胞弥漫浸润肺间质；对糖皮质激素和免疫抑制剂反映良好。结论LIP影像、病理具有特征性，糖皮质激素治疗效果好。

Objective To explore the diagnosis and treatment of secondary lymphoid interstitial pneumonia （LIP） by analyzing the clinical manifestation, imaging manifestation and histopathological characteristics of LIP. Methods The clinical, chest computed tomography （CT） and histopathological characteristics of two cases of definite LIP was retrospectively analyzed and literature was reviewed and summarized. Results Both two patients suffered from secondary I.IP caused by Sjogrens syndrome. Clinically, patients were mainly presented with progressive chest distress and dyspnea. CT of chest revealed diffusely distributed thin-walled cavity with nodules. Main histologic feature of LIP was diffuse interstitial infiltrates of iymphocytes. Both patients had responded well to giucocorticoid and immunosuppressant. Conclusions Imaging manifestation and histopathological characteristics of LIP are characterful. LIP responds well to glucocorticoid.