蛋白质巯基-亚硝基化修饰在肺部疾病及脓毒症中作用的研究进展

Role of S-nitrosylation in pumonary diseases and sepsis

蛋白质巯基-亚硝基化修饰（Snitrosylation，以下简称s_亚硝基化）是一种新发现的蛋白质翻译后修饰方式，即一氧化氮（nitricoxide，NO）作用于蛋白质半胱氨酸巯基生成亚硝基琉醇。孓亚硝基化调控生物体内多种蛋白质的功能和活性，而由NO介导的S-亚硝基化已被证实参与了肺内细胞凋亡、气道高反应性、肺动脉压增高、炎症反应、免疫抑制等多个病理生理过程，本文就S-亚硝基化在肺部疾病及脓毒症发生发展过程所起的作用综述如下。

S-nitrosylation is a newly discovered posttranslational modification which refferes to covalent reaction of nitric oxide with a cysteine thiol group on the target protein, generating s- nitrosothiols. S-nitrosylation regulates functions and activities of many proteins in vivo, and nitric oxide- mediated S-nitrosylation has been demonstrated to be involved in the apoptosis of pulmonary cells,airway hyperresponsiveness,increased pulmonary artery pressure, inflammation, immune suppression and other pathological and physiological processes. This review will focus on the effect of S-nitrosylation on the development of pumonary diseases and sepsis.