基质金属蛋白酶在ARDS发病机制中的作用

Effect of matrix metalloproteinases in the pathogenesis of acute respiratory distress syndrome

基质金属蛋白酶是一组结构和功能相似、锌依赖性内肽酶的总称，主要功能是降解细胞外基质。ARDS是以顽固性低氧血症、非心源性肺水肿及炎症反应的过度与失控为特点的急性呼吸衰竭综合征。基质金属蛋白酶可通过蛋白水解作用激活并释放细胞因子及化学因子、破坏肺泡一上皮细胞屏障完整性、激活蛋白酪氨酸激酶（protein tyrosine kinases，PTKs）信号通路等作用促进ARDS的发生、发展。

Matrix metalloproteinases,a large family of zinc-dependent endopeptidases,are the main function to degrade the extracellular matrix. Acute respiratory distress syndrome（ARDS）, a syndrome of acute respiratory failure, is characterized by refractory hypoxemia, noncardiogenic pulmonary edema and dysregulated and excessive inflammation. Matrix metalloproteinases can promote the occurrence and development of ARDS by proteolytic processing,including cytokines and chemical factors activation and release,destruction of the integrity of alveolar-epithelial barrier and activation of the protein tyrosine kinase signaling pathway.