摘要
目的探讨10例侧脑室注射STZ术后出现肠梗阻大鼠的治疗方案,提高该术后大鼠的存活率。方法予60只大鼠侧脑室注射STZ观察1周后,选取其中出现不同程度肠梗阻大鼠10例用开塞露灌肠,大黄水灌胃并间断给予软食的方法治疗。结果治愈2例,无效死亡8例,死亡大鼠尸检结果为中位梗阻伴见肠胀气,偶见穿孔、坏死等。结论该治疗方案简单有效,有利于提高侧脑室注射STZ术后存活率,但使用时也有一些注意事项。
Objective To study the therapeutic effects of rats with intestinal obstruction induced by intraventricular injection of STZ in order to improve postoperative survival rate. Method STZ were given intraventricular injection to 60 rats and one week after injection 10 rats with intestinal obstruction were selected for evaluation of therapeutic effects of glycerine enema and radix et rhizoma Rhei water,at the same time the rates were supplied with soft food.Then the therapeutic effect was evaluated by the following parameters： food intake,fur color,mental health,emotional reactions,body temperature,stool and urine. Result During the therapeutic period 2 rats survived and8 died（ autopsy results revealed the intermediate obstruction,usually with intestinal flatulence,perforation,necrosis. Conclusion The combined therapy with Chinese and Western medicine is simple and relatively successful（ especially the treatment started within 3—5 days after onset）.
出处
《实验动物科学》
2015年第4期49-50,58,共3页
Laboratory Animal Science
基金
武警总部专项课题(No.2011003)
关键词
侧脑室注射STZ
肠梗阻
大黄灌胃
Intraventricular injection STZ
Intestinal obstruction
Radix et rhizoma Rhei
