小牛脾提取物注射液辅助化疗治疗肿瘤疗效与安全性的Meta分析

Efficacy and Safety of Calf Spleen Extract Injection Combined with Chemotherapy in the Treatment of Cancer:A Meta-analysis

目的:系统评价小牛脾提取物注射液辅助化疗治疗肿瘤的疗效与安全性,以为临床治疗提供循证参考。方法:计算机检索Cochrane图书馆、Pub Med、Medline、EMBase、中国期刊全文数据库、万方数据库和中文科技期刊数据库,收集小牛脾提取物注射液辅助化疗治疗肿瘤的随机对照试验(RCT),对符合纳入标准的临床研究进行资料提取,采用Cochrane系统评价员手册5.0版进行质量评价,采用Rev Man 5.0统计软件进行Meta分析。结果:共纳入23项RCT,合计1 682例患者。Meta分析结果显示,小牛脾提取物注射液辅助化疗治疗肿瘤能显著提高有效率[OR=2.17,95%CI(1.68,2.81),P<0.001]和生存质量改善率[OR=4.26,95%CI(2.47,7.32),P<0.001],同时还能降低白细胞、血小板减少率和恶心、呕吐等发生率,差异均有统计学意义。结论:小牛脾提取物注射液辅助化疗治疗肿瘤的疗效与安全性均较好。

OBJECTIVE：To systematically review the efficacy and safety of Calf spleen extract injection combined with chemo-therapy in the treatment of cancer,and provide evidence-based reference for clinical treatment. METHODS：Retrieved from Co-chrane Library,PubMed,Medline,EMBase,CJFD,Wanfang and VIP Database,randomized controlled trials（RCT）of the effica-cy and safety about Calf spleen extract injection combined with chemotherapy in the treatment of cancer were collected. Meta-analy-sis was performed by using Rev Man 5.0 software after data extract and quality evaluation by Cochrane 5.0. RESULTS：Totally 23 RCT were enrolled,including 1 682 patients. Results of Meta-analysis showed Calf spleen extract injection combined with chemo-therapy in the treatment of cancer can significantly improve the effective rate [OR=2.17,95%CI（1.68,2.81）,P〈0.001] and im-provement rate of life quality [OR=4.26,95%CI（2.47,7.32）,P〈0.001] and also reduce the degree rate of WBC and PLT,the inci-dence rate of nausea and emesis,the differences were statistically significant. CONCLUSIONS：Calf spleen extraction injection combined with chemotherapy has good efficacy and safety in the treatment of cancer.