CD24表达与宫颈癌预后关系的研究进展

Progress of the relationship between CD24 expression and the prognosis of cervical cancer

CD24是一种新近发现并重点研究的肿瘤标志物,它是细胞黏附分子之一,能介导细胞与细胞、细胞与细胞外基质间的黏附。研究发现CD24在人类多种癌症中有较高的表达率,认为CD24在多种肿瘤的进展及转移中发挥重要的作用,CD24阳性表达则肿瘤预后更差。CD24在宫颈癌中的表达情况目前研究尚少,现有报道均提示其表达率较高,认为过表达CD24的宫颈癌容易复发及转移,与预后相关。CD24阳性可为临床治疗及预后判断提供重要的提示,为治疗策略的制定提供参考,有望成为宫颈癌的检测指标。该文对CD24表达与宫颈癌预后关系的研究进展作一综述。

CD24 is an adhesion molecule as a newly discovered tumor marker and many studies have dis- cussed the prognostic value of CD24 for different tumors recently. CD24 is a small cell surface protein molecule an- chored by glycosyl phosphatidyl inositol in a wide variety of cancer cells which mediate adhesion and functions of cell- cell and cell-matrix interactions. Many studies indicated that CD24 expression was found in a variety of human tumors and was considered to be linked with invasion, metastasis and a poor prognosis of tumors. The present studies suggest that CD24 overexpression is a predictor of invasion, distant metastasis, decreased long-term survival and poor progno- sis in patients with cervical cancer. Understanding and detection of CD24 expression in cervical cancer may provide some important clinical implications for therapeutic decision and prognosis judgement, and conduct some guides for the establishment of treatment strategy. CD24 may become an important biological marker to detect cervical cancer. The relationship between CD24 expression and the prognosis of cervical cancer is reviewed in this paper.