内镜下氩离子凝固术与奥美拉唑联用对68例巴雷特食管患者的临床疗效观察

Clinial Observation on Therapeutic Effect of the Combination of Endoscopic Argon Plasma Coagulation and Omeprazole on 68 Patients with Bartleys Esophagus

目的研究内镜下氩离子凝固术与奥美拉唑联用对巴雷特食管患者的临床疗效。方法选择2013-03~2015-03间来茂名市中医院就诊的68例巴雷特食管患者作为研究对象,以数字随机法将其分成观察组（34例）和对照组（34例）。对照组单用奥美拉唑治疗,而观察组则联用奥美拉唑与氩离子凝固术治疗。比较两组患者的临床疗效、术后不良反应以及随访复发率。结果观察组的治愈有效率为97.06%,显著高于对照组79.41%;观察组患者病灶总复发率为14.71%,显著低于对照组的38.24%,差异有统计学意义（P〈0.05）。两组患者最终总不良反应率差异不显著。结论奥美拉唑与内镜下氩离子凝固术的联合治疗巴雷特食管的效果更好,能有效降低病灶复发率,值得临床推荐。

Objective To study clinical efficacy of endoscopic argon plasma coagulation combined with omeprazole in the treatment of 68 cases of Barrett＇s esophagus. Methods From March 2013 to March 2015, 68 cases of Bailey esophagus patients were selected as the research object, according to random number method divided into observation group （34 cases） and control group （34 cases）. The control group was treated with omeprazole treatment, and the observation group with omeprazole combined with argon plasma coagulation treatment. The clinical efficacy, adverse reactions and recurrence rate were compared between the two groups. Results In the observation group, the cure rate was 97.06%, which was significantly higher than that of the control group （79.41%） ; which had no statistical significance be- tween the rate of two groups of patients eventually total adverse reaction; observation group of patients with lesion recurrence rate was 14. 71%, which was significantly lower than the control group （38. 24% ）. Conclusion Omeprazole and endoscopic argon plasma coagu- lation combined with omeprazole in the treatment of Bailey esophageal had good effect and low recurrence rate, which was worth of clinical recommendations.