GLP-1与2型糖尿病的研究进展

Progress in GLP-1 and type 2 diabetes mellitus research

胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)具有促进胰岛素分泌、保护胰岛β细胞、降低食欲等多种重要功能,在控制体内血糖平衡的过程中发挥重要作用。2型糖尿病的发生伴随着胰高血糖素样肽-1生物应答功能受损。胰高血糖素样肽-1类似物、胰高血糖素样肽-1受体激动剂和胰高血糖素样肽-1降解酶抑制剂等糖尿病治疗药物已在临床上表现出很好的应用前景。

Glucagon-like peptide-1 has multiple functions. It can promote insulin secretion, protect islet cells, reduce appetite, and play an important role to control blood glucose homeostasis. The pathogenesis of type 2 diabetes mellitus accompanied by impaired biological response of glucagon-like peptide-1. Therapeutics drugs for diabetes, such as glucagon-like peptide-1 analogues, glucagon-like peptide-1 receptor agonists and glucagon-like peptide-1 degradation enzyme inhibitors have showed a good application prospect in clinic.