AKR1B10,一个新型肿瘤分子诊断标志物

AKR1B10, a novel tumor molecular marker

AKR1B10是一种醛酮还原酶,主要功能是还原醛酮类羰基化合物,并且能够通过减少乙酰辅酶A羧化酶α的降解,调节脂质的合成。AKR1B10在正常胃肠道上皮组织中高表达,在其他正常组织中低表达或不表达;但AKR1B10在乳腺癌、肝癌、非小细胞肺癌等肿瘤中都有明显高表达,因此AKR1B10可作为一个肿瘤的病理诊断标志物。AKR1B10是一个分泌性蛋白,在乳腺癌患者血清AKR1B10浓度显著升高,因此它可以作为肿瘤的血清标志物。由于其与肿瘤发生发展有着密切的关系,因此可能作为治疗恶性肿瘤的新靶位。

AKR1B10 is a member of aldehyde ketone reductase family and its main function is to restore carbonyl compounds. AKR1B10 regulates lipid synthesis by reducing acetyl-coa carboxylase α degradation. AKR1B10 is expressed highly in epithelial tissues of gastrointestinal tracts, however with low or no expression in the other normal tissues. AKR1B10 have a significantly higher expression in some cancers such as breast cancer, liver cancer, and non-small cell lung cancer, thus can be used as a serum marker of cancer as well as the pathological markers to diagnose malignant tumor. At the same time, because it has a close relationship with tumor formation and development, it is possible AKR1B10 is taken as a new target for the treatment of malignant tumor.