GPER与细胞增殖的研究进展

Research progress on GPER and cell proliferation

G蛋白偶联雌激素受体(G protein-coupled estrogen receptor,GPER)是一种与经典雌激素受体(ER)不同的新型雌激素受体,自20世纪90年代末期被发现以来,一直受到研究者的广泛关注。越来越多的证据表明GPER与癌症和心血管疾病的发生和发展关系密切,可能成为疾病治疗的新靶点,但目前对GPER的某些功能认知尚存争议。本文在简单介绍GPER的发现、结构、定位、特异性配体及参与的信号转导途径的基础上,着重就GPER与不同细胞增殖及其与相关疾病之间的关系进行阐述,以期进一步理解GPER及其在信号传导、细胞增殖及疾病防治中的作用。

The G protein-coupled estrogen receptor（GPER）, a novel estrogen receptor that differs from classical estrogen receptors（ERs）, is discovered in the late 1990 s. Since then, GPER is gaining attention and widely research. More and more evidence has indicated that GPER is involved in the occurrence and development of cancer and cardiovascular disease, and may represent a new target to combat these disease. While recent reports regarding the location and function of GPER on the growth of cancer cells are controversial. In this review, the intrinsic appearance of GPER, including structure, subcellular localization, ligands and signal transduction pathway is simply introduced, the role of GPER in various cells proliferation and its relationship with diseases are mainly discussed in order to further understand the GPER and its roles in signal transduction, cell proliferation and disease prevention and treatment.