中西医结合治疗9例HIV/AIDS相关性非感染性皮损患者的临床疗效观察

Clinical Efficacy of Integrative Medicine in Treatment of Nine HIV/AIDS-associated Non-infectious Skin Lesion Cases

目的:通过观察高效抗逆转录病毒治疗(Highly Active Antiretroviral Therapy,HAART)联合平艾合剂治疗人类免疫缺陷病毒/获得性免疫缺陷综合征(Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome,HIV/AIDS,简称"艾滋病")相关性非感染性皮损患者的临床疗效,进一步研究中西医结合在艾滋病防治中的优势。方法:选取符合纳入标准的9名气阴两虚、痰瘀内阻型艾滋病相关性非感染性皮损患者,采用HAART联合平艾合剂1和4号方治疗3个月,观察患者治疗前后临床症状、体征、卡洛夫斯基积分及CD4+T淋巴细胞的变化,采用STATA 12.0进行统计分析。结果:中西医结合治疗后患者皮肤斑丘疹、皮下结节、皮肤瘙痒、乏力等症状体征的单独积分较疗前明显减少,总积分较疗前降低。患者生存质量明显提高,卡洛夫斯基积分较疗前升高。CD4+T淋巴细胞值较疗前升高。结论:该中西医结合疗法对艾滋病患者相关性非感染性皮损具有一定疗效,可改善临床症状、体征,明显提高患者生存质量,提高患者免疫功能。

This study was aimed to observe the clinical efficacy of Highly Active Antiretroviral Therapy（HAART） combined with Ping-Ai（PA） Mixture in the treatment of Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome（HIV/AIDS） patients with non-infectious skin lesions, in order to study the advantages of integrative medicine in AIDS prevention and treatment. A total of 9 cases, who met the inclusion criteria of AIDS-associated non-infectious skin lesion with the pattern of qi-yin deficiency and internal obstruction of phlegm-stasis, were selected. The combination of HAART and number 1 and 4 prescription of PA Mixture were used in the treatment for 3 months. The observations were made on changes of clinical symptoms, body signs, Karovsky integral and CD4＋ T cells of patients before and after treatment. Stata 12.0 was used in the statistical analysis. The results showed that after integrative therapy, the single integral of clinical symptoms and body signs, such as skin spot papula, subcutaneous nodules, skin itching, fatigue was obviously reduced compared to that of the pretreatment. The total score decreased than that of the pretreatment. The patients＇ quality of life（QOL） significantly increased. The Karovsky integral increased compared with that of pretreatment. The CD4＋ T cells values were higher than that of the pretreatment. It was concluded that the integrative therapy had a certain effect in the treatment of AIDS-associated non-infectious skin lesions, which can improve the clinical symptoms, body signs, obviously increase the patients＇ QOL and immune function.