中药联合双磷酸盐治疗恶性肿瘤骨转移疗效的Meta分析

Traditional Chinese Medicine Decoction Combined Bisphosphonates in Treatment of Bone Metastasis of Malignant Tumors: A Systematic Reviews and Meta-analysis

目的:通过对比双磷酸盐联合传统中药汤剂与单纯双磷酸盐治疗恶性肿瘤骨转移的疗效,来验证传统中医药治疗恶性肿瘤骨转移的作用和优势。方法:计算机检索Pub Med、Embase、CBM、CNKI和Cochrane Databases中的相关文献,结局指标包括疼痛缓解评价、活动能力改善评价、骨质修评价、KPS改善评价以及毒副反应。运用Meta分析软件Stata 11.0进行统计分析。结果:共纳入研究19篇,涉及患者人数为1 080,结果提示双磷酸盐联合传统中药汤剂组能显著改善疼痛症状(RR=0.807 9,95%CI=0.754-0.85,P<0.001)、改善活动能力(RR=0.787,95%CI=0.69-0.897,P<0.001)、改善骨质破坏(RR=0.71,95%CI=0.52-0.96,P=0.026)、提高KPS(RR=0.726 8,95%CI=0.61-0.85,0.58-0.81,P<0.001)。结论:双磷酸盐联合传统中药汤剂治疗恶性肿瘤骨转移能够显著提高其疗效,同时改善患者的生活质量。

This study was aimed to systematically appraise the effectiveness and safety of traditional Chinese medicine（TCM） decoction in combination with bisphosphonates in treatment of bone metastasis of malignant tumors. Related literatures were searched in the Pub Med, Embase, CBM, CNKI and Cochrane Databases. The endpoints included cancer pain, activity of daily living, sclerotin reparation, KPS and adverse events. The Stata 11.0 software was used in the statistical analysis. The results showed that a total of 19 articles involving 1080 patients were included. It showed that TCM in combination with bisphosphonates can significantly relieve pain（RR = 0.8079, 95%CI = 0.754- 0.85, P〈0.001）, improve the activity of daily living（RR = 0.787, 95%CI = 0.69-0.897, P〈0.001）, promote sclerotin reparation（RR = 0.71, 95%CI = 0.52-0.96, P = 0.026）, and improve KPS（RR = 0.7268, 95%CI = 0.61-0.85, 0.58-0.81, P〈0.001）. It was concluded that TCM decoction in combination with bisphosphonates can significantly improve its therapeutic effect as well as improve the patients＇ quality of life.