低频超声促透独活寄生汤治疗膝骨关节炎的临床研究

Clinical Study on Du-Huo Ji-Sheng Decoction with Low Frequency Ultrasonics in Treatment of Knee Osteoarthritis

目的:通过观察低频超声促透独活寄生汤治疗膝骨关节炎(Knee Osteoarthritis,KOA)患者的膝关节的视觉疼痛模拟评分(Visual Analogue Scale,VAS)、Lysholm评分和血清转化生长因子(Transforming Growth Factor-β,TGF-β)及金属蛋白酶3(Matrix Metalloproteinase-3,MMP-3),以研究此疗法治疗KOA的临床疗效。方法:将来自门诊的60例KOA确诊患者按随机数字表法分为治疗组和对照组,每组各30例,治疗组采用低频超声促透独活寄生汤治疗;对照组促透布洛芬凝胶,治疗均每日1次,持续2周。治疗前后分别对患者进行VAS、Lysholm功能评分,以酶联免疫吸附法(ELISA)检测患者血清中TGF-β及MMP-3表达水平。结果:低频超声促透独活寄生汤较对照组能够明显减轻KOA患者疼痛,提高关节活动功能,增加血清中TGF-β含量,降低MMP-3水平。结论:低频超声促透独活寄生汤能够有效缓解KOA患者临床症状。

This study was aimed to observe the clinical effect of Du-Huo Ji-Sheng（DHJS） decoction with low frequency ultrasonics in treatment of knee osteoarthritis（KOA） by evaluating the visual analogue scale（VAS）, Lysholm score and the expression levels of transforming growth factor-β（TGF-β） and matrix metalloproteinase-3（MMP-3）. A total of 60 KOA outpatients were randomly divided into the treatment group and the control group, with 30 cases in each group. Patients in the treatment group were treated with DHJS decoction and low frequency ultrasonics therapy, while patients in the control group were treated with ibuprofen and low frequency ultrasonics. The treatment was given once a day for two weeks. The pretreatment and posttreatment VAS, Lysholm score and expression levels of TGF-β and MMP-3, which were detected by ELISA, were recorded. The results showed that compared with the control group, DHJS decoction with low frequency ultrasonics therapy could alleviate pain as well as improve the activity of joint function among KOA patients. It could also increase the content of TGF-βin serum, and suppress the level of MMP-3. It was concluded that low frequency ultrasonics could enhance the transdermal absorption of DHJS decoction, relieve the clinical symptoms of KOA patients.