高同型半胱氨酸血症患者血小板参数检测的临床意义

The clinical significance of the detection of platelet parameters in patients with hyperhomocysteinemia

目的观察高同型半胱氨酸血症(HHcy)患者血小板参数的变化,并对其临床价值做初步评价。方法检测65例HHcy患者,50例健康体检者(正常对照组)的血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)及大血小板比率(P-LCR)水平,分析Hcy与PLT、MPV、PCT、PDW及P-LCR的相关性。结果HHcy患者PLT、MPV、PDW及P-LCR水平与对照比较,均明显增高,差异均具有统计学意义(P<0.05),PCT水平与对照组比较,差异无统计学意义(P>0.05)。HHcy患者血清Hcy水平与MPV、PDW及P-LCR呈明显正相关(P<0.05)。结论 HHcy患者血小板参数变化明显,提示Hcy可以通过增加血小板活性,在血栓性疾病发生、发展中起重要的作用。

Objective To observe the changes of platelet parameters in patients with hyperhomocysteinemia（ HHcy）,and to evaluate the clinical value primarily. Methods A total of 65 HHcy patients and 50 healthy subjects（ healthy control group）were enrolled for determining the levels of platelet count（ PLT）,mean platelet volume（ MPV）,plateletcrit（ PCT）,platelet distribution width（ PDW） and platelet- large cell ratio（ P- LCR）. The correlation of homocysteinemia（ Hcy） with PLT,MPV,PCT,PDW and P- LCR was analyzed. Results The levels of PLT,MPV,PDW and P- LCR in patients with HHcy were higher than that in healthy control group,and the differences were statistically significant（ P〈0. 05）; the PCT results show that there is no statistical significance on the difference between patients with hyperhomocysteinemia and the control group（ P〈0. 05）. The correlation of Hcy with MPV,PDW,P- LCR were positive（ P〈0. 05）. Conclusion There is a significant change of platelet parameters in patients with hyperhomocysteinemia,suggesting that Hcy plays an important role in the occurrence and development of thrombotic diseases by increasing the platelet activity.