磺胺嘧啶银霜联合重组人粒细胞巨噬细胞刺激因子凝胶治疗深Ⅱ度烧伤创面的疗效评价

Evaluation of Therapeutic Effect of Recombinant Human Granulocyte-macrophage Colony-stimulating Factor Combined with SD-Ag Unguent on Deep Second Degree Burn

目的通过调查分析评价重组人粒细胞巨噬细胞刺激因子(rh GM-CSF)凝胶联合应用磺胺嘧啶银(SDAg)霜对深Ⅱ度烧伤创面愈合的疗效。方法收集深Ⅱ度烧伤创面(总面积<10%)患者89例,按创面用药情况将患者分成A组(SD-Ag霜)和B组(rh GM-CSF凝胶+SD-Ag霜),观察比较两组创面愈合率、上皮化时间及不良反应。结果创面上皮化时间:A组、B组分别为(19.79±1.47),(15.76±1.63)d,B组显著短于A组;创面愈合率:伤后9,13,16,21 d创面愈合率A组、B组分别为(67.24±2.33)%,(75.54±1.11)%,(88.33±1.32)%,(99.14±1.95)%和(76.41±3.24)%,(95.01±1.43)%,(99.54±0.88)%,(100.00±0.00)%,组间同期比较B组均优于A组;治疗期间两组均未见明显不良反应。结论 SD-Ag霜联合外用rh GM-CSF凝胶剂能促进深Ⅱ度烧伤创面愈合,疗效确切安全。

Objective To evaluate the therapeutic effect of recombinant human granulocyte-macrophage colony stimulating factor （rhGM-CSF） combined with sulfadiazine sliver （SD-Ag） unguent on deep second degree burn. Methods Eighty-nine patients with deep second-degree burn （burns areas〈 10% ） were enrolled.These patients were divided into two groups at random （Group A and Group B）.The patients in Group A were treated with SD-Ag unguent only, and those in Group B were treated with rhGM-CSF and SD-Ag unguent.The therapeutic effects and the adverse drug reaction were recorded. Results The healing time in Group A [ （19.79±1.47） days] was obviously shorter than that in Group B [ （15.76±1.63） days].The total wound healing rates in Group B [on day 9： （76.41±3.24）%, day 13： （95.01±1.43）%, day 16： （99.54±0.88）%, and day 21 （100.00±0.00）%] were higher than those of Group A [on day 9： （67.24±2.33）%, day 13： （75.54±1.11）%, day 16： （88.33±1.32） %, day 21： （99.14±1.95）% ].During the treatment, there was no obvious adverse reaction was observed in the two groups. Conclusion The application of rhGM-CSF combined with SD-Ag unguent can not only accelerate the healing rates of deep second-degree burn, but also has curative effect with safety.