TREK-1钾通道介导的抗抑郁及神经保护作用

The antidepressant and neuroprotective effect mediated by TREK-1 potassium channel

目的系统分析TREK-1的结构功能及发挥这-作用的相关机制，以期为临床疾病的治疗提供新思路。方法计算机检索Medline／PubMed、CNKI、CBM及万方数据库中关于TREK-1及相关抗抑郁及神经保护的文献，提取TREK-1钾通道的结构功能及生理药理学相关介绍以及潜在的抗抑郁及神经保护作用机制相关研究，并对纳入文献的参考文献进行查询，检索期限为建库至2015年10月。结果文章最终纳入文献30篇，涉及TREK-1结构分布及调控因素的有14篇，TREK-1介导的抗抑郁研究13篇。TREK-1发挥神经保护作用的研究7篇。综上研究发现阻断或抑制TREK-1钾通道活性，产生显著的抗抑郁作用；激活该通道可扩张局部脑血管，抑制异常活跃放电的神经元。结论TREK-1钾通道在体内的抗抑郁及脑保护作用的研究已取得重要进展，下-步的研究应聚焦在探讨不同脑区TREK．1的最佳激活比例，以获得临床上抗抑郁及神经保护效果的最佳平衡。

Objective Recently, the role of TREK-1 in anti-depression and neuroprotection was demon- strated definitely. In this paper,a systematic review about the functional structure of TREK-1 as well as the under- lying mechanisms which involved in depression resistance and nerve protection was made for purpose of providing new ideas for the treatment of clinical diseases. Methods The electronic search of Medline/PubMed, CNKI, CBM and Wanfang Data were performed to collect the introduction of TREK-1 and the studies of depression and nerve protection in which TREK-1 participated from inception of each database to October 2015, besides the relevant ref- erences of the included studies were also retrieved. Results 30 studies were included in this paper. 14 studies were about the interpretation of TREK-I＇s structure, distribution and the regulatory factors,and the number of re- searches regarding the involvement of TREK-1 in anti-depression and neuroprotection was 13 and 7 respectively. Based on these studies, it was easily to conclude that inhibition or blocking of TREK-1 channels can produce obvi- ous antidepressant effect ,however,activation of TREK-1 channels will induce the dilation of local cerebral vascular and silence hyperactive neurons. Conclusion Some achievements about the antidepressant and neuroprotective effect of TREK-1 channels in vivo have been made gratifyingly,thus future research should focus on exploring the best TREK-lactivation ratio in different brain regions to gain the best balance between anti-depression and neuro- protection.