噻托溴铵辅助高剂量糖皮质激素治疗重症哮喘的效果分析

Effect of high-dose glucocorticoids combined with the adjuvant therapy of tiotropium bromide on severe asthma

目的:探讨大剂量糖皮质激素联合噻托溴铵辅助治疗重症哮喘患者的疗效。方法:将80例重症哮喘的患者随机分为观察组和对照组各40例,在常规治疗的基础上,对照组给予甲泼尼龙3.0mg·kg^(-1)·d^(-1)治疗,观察组给予甲泼尼龙3.0mg·kg^(-1)·d^(-1)联合噻托溴铵18μg/d治疗,比较患者治疗前后临床症状的变化、肺功能、血气指标、随访结果以及不良反应。结果:治疗后研究组患者临床症状改善优于对照组(P<0.05)。治疗后观察组患者肺功能和血气指标改善优于对照组(P<0.05)。观察组随访情况优于对照组(P<0.05)。两组患者不良反应发生率无统计学差异(P>0.05)。结论:大剂量糖皮质激素联合噻托溴铵辅助治疗重症哮喘疗效好,不良反应轻。

Objective：To investigate the efficacy of high-dose glucocorticoids combined with the adjuvant therapy of tiotropium bromide on severe asthma.Methods：80 cases of severe asthma were randomized into the observation group and the control group with 40 cases in each.Both groups adopted the high-dose glucocorticoids therapy on the basis of conventional treatment.Of which,the control group were treated with methylprednisolone at the dosage of 3.0mg·kg^-1·d^-1,while the observation group adopted the combined treatment with methylprednisolone at the dose of 3.0mg·kg^-1·d^-1 and tiotropium bromide at the dose of 18μg/d.Then the changes of the clinical symptoms,pulmonary functions and blood gas index,follow-up results and adverse reaction of both groups before and after the treatment were compared.Results：After the treatment,the changes of the clinical symptoms,pulmonary functions and blood gas index of the observation group had been improved more significantly（P〈0.05）,and the follow-up results in the observation group was better（P〈0.05）.But there was no statistical difference of the adverse reaction between both groups（P〉0.05）.Conclusion：High-dose glucocorticoids combined with the adjuvant therapy of tiotropium bromide in treating severe asthma will be more effective and shows no severe adverse reaction.