摘要
目的:探讨多模态CT预测自发性蛛网膜下腔出血(SAH)患者迟发性脑梗死(DCI)的价值。方法:随机对82例自发性SAH患者进行多模态CT检查,所有患者发病72 h内急诊行多层螺旋头颅CT平扫、CT灌注成像(CTP)及CT血管造影(CTA)检查,并于发病14 d内行CT平扫随访,根据两次CT平扫结果判断是否发生DCI,将患者分为DCI组(n=30)和无DCI组(NDCI组,n=52)。结果:发病72 h内,2组CTP定量比较,DCI组与NDCI组平均相对脑血流量(r CBF)分别为0.82和1.02(P<0.01),平均相对脑血容量(r CBV)为0.90和1.03(P<0.01),平均相对通过时间(r MTT)分别为1.24和0.97(P<0.01),SAH的初期,DCI组的脑血流动力学已经发生改变。CTP预测DCI的敏感性、特异性分别为100.0%、42.3%,假阴性率为0,假阳性率57.7%。而CTA预测DCI的敏感性、特异性分别为20.0%、88.5%,假阴性率为80.0%,假阳性率为11.5%。结论:CTP联合CTA检查,有助于临床医生全面了解SAH的脑血管形态和脑组织灌注情况,定量了解脑组织血流动力学变化情况,对早期预判DCI及其范围、指导临床早期干预治疗具有重要的意义。
Objective： To investigate the value of Multi-mode CT scan in predicting delayed cerebral infarction（DCI） after spontaneous subarachnoid hemorrhage（SSAH）. Methods： Eighty-two patients were scanned with head Multi-mode CT in 72 hours after SSAH attacking, including plain CT scan, computer tomography angiography（CTA） scan and computer tomography perfusion（CTP） scan. All of the 82 patients received plain CT scan again in 14 days. A total of 82 patients were classified into two groups： DCI group（n=30） and NDCI group（n=52）. Results： After quantitative comparison of CTP of both groups, the average r CBF was 0.82 and 1.02（P〈0.01）, the average r CBV was 0.90 and 1.03（P〈0.01）, and the average r MTT was 1.24 and 0.97（P〈0.01）. Brain hemodynamics began to change in early days in SAH patients. The sensitivity, specificity, false negative rates and false positive rates of CTP and CTA＇s value in predicting DCI were 100.0%, 42.3%, 0, 57.7% and 20.0%, 88.5%, 80.0%, 11.5%, respectively. All of these were calculated at the base of plain CT scan. Conclusion： Brain CTA combined with CTP will be helpful for clinician to comprehend the shape of cerebral vessel and the perfusion of brain tissue in patients with SAH. The brain blood flow changes can be known quantitatively. Also it is meaningful in early predicating DCI and its range, and guiding the early intervention of the DCI.
出处
《温州医科大学学报》
CAS
2015年第12期879-882,886,共5页
Journal of Wenzhou Medical University
基金
温州市科技计划项目(Y20140027
Y20140733)
