补肾活血开窍方对治疗糖尿病所致血管性认知功能障碍的发展的有效性分析

An effective analysis of treating vascular cognitive impairment from diabetes with the Bushen Huoxue Kaiqiao decoction

目的:观察补肾活血开窍方治疗糖尿病所致血管性认知功能障碍(Cognitive Impairment,CI)的临床有效性。方法:分析东漖街社区服务中心于2013年1月-2014年7月收治的54例糖尿病所致血管性认知功能障碍患者,按照随机数字表法分为治疗组与对照组。对照组26例,给予口服尼莫地平;治疗组28例,在对照组的基础上加用补肾活血开窍方。比较两组治疗后痴呆评定量表(Clinical Dementia Rating,CDR)评分;Mo Ca量表和日常生活能力量表(ADL);认知功能简易智力状态量表(MMSE)评分;不良反应。结果:两组患者治疗后与同组治疗前CDR、Mo Ca、ADL评分比较,P<0.05。两组治疗前后即刻回忆力、记忆力、注意力、定向力、语言能力以及总分比较,P<0.05。两组不良反应发生率分别为23.1%(6/26),10.7%(3/28),两组比较,P>0.05。结论:补肾活血开窍方治疗糖尿病所致血管性CI疗效确切,可改善患者的CDR、Mo Ca、ADL、MMSE评分,且不增加不良反应,有临床推广应用的价值。

Objective： To observe clinical efficacy of the Bushen Huoxue Kaiqiao decoction on vascular cognitive impairment from diabetes. Methods： 54 cases were divided into the treatment group and control group. 26 cases in the control group took Nimodipine; 28 cases in the treatment group took the Bushen Huoxue Kaiqiao decoction more. Adverse reactions and scores of CDR, MoCa, ADL and MMSE were compared. Results： The differences of CDR, MoCa and ADL were significant before and after treatment. Before and after treatment, the differences of immediate recall, memory, attention, orientation, language ability and total score were statistically significant. Adverse reactions in two groups were 23.1% （6/26） and 10.7% （3/28） respectively （P〉0.05）. Conclusion： The Bushen Huoxue Kaiqiao decoction was effective on vascular cognitive impairment from diabetes, with improved scores of CDR, MoCa, ADL and MMS, and was worthy of promotion.