泼尼松联合小柴胡汤治疗系统性红斑狼疮的临床效果研究

Clinical study of cortical hormone combined with Xiaochaihu Decoction in the treatment of systemic lupus erythematosus

目的:探究皮质激素联合小柴胡汤治疗系统性红斑狼疮的临床疗效。方法:选取2012年1月—2014年12月我院收治的100例系统性红斑狼疮患者作为研究对象,患者均符合美国风湿病学会(ACR)制定的相关标准,入院后采用数字表法随机将患者分为观察组和对照组各50例,对照组采用氢化泼尼松注射液治疗,观察组则在对照组基础上加用小柴胡汤治疗,对比两组患者的SLEDAI、CRP、ESR、补体C3、补体C4、尿蛋白及不良反应等指标。结果:治疗前两组患者的各项指标对比均无显著差异(P>0.05);治疗后观察组患者的SLEDAI、CRP、ESR水平显著低于对照组,补体C3水平显著高于对照组,差异具有统计学意义(P<0.05);观察组的总体不良反应率为2.0%,显著低于对照组的10.0%,差异具有统计学意义(P<0.05)。结论:皮质激素联合小柴胡汤治疗系统性红斑狼疮能够有效地控制系统性红斑狼疮活动,降低C-反应蛋白和血沉水平,提高补体C3水平,且用药安全性明显高于单纯应用皮质激素,值得在临床上推广和应用。

Objective： To explore and study the clinical therapeutic effect of cortical hormone combined with Xiaochaihu Decoction in the treatment of systemic lupus erythematosus. Methods： 100 patients of systemic lupus erythematosus, who were consistent with the relevant standards formulated by American rheumatism association （ACR） and admitted to our hospital from January 2012 to December 2014, were randomly divided observation group and control group evenly, the observation group received cortical hormone combined with Xiaochaihu Decoction and the control group received hydrogenated prednisone injection, index such as systemic lupus erythematosus activity index （SLEDAI）, c-reactive protein （CRP）, erythrocyte sedimentation rate （ESR）, complement C3, complement C41 urine protein and adverse reactions were compared and the therapeutic effect of two groups were observed. Results： Before treatment, the difference of index of two groups was statistically insignificant （P〉0.05） , after treatment, the SLEDAI, CRP, ESR of the observation patients were significantly lower than that of the control group while the C3 level is significantly higher than that of the control group, the difference was statistically significant （P〈 0.05）. The overall adverse reaction rate of the observation group was 2.0%, which was significantly lower than that of the control group, 10.0%, the difference was statistically significant （P〈0.05）. Conclusion： Cortical hormone combined with Xiaochaihu Decoction could effectively control systemic lupus erythematosus （sle） activity, decrease the level of c-reactive protein and blood sedimentation in addition to raising the level of C3, the combination was significantly safer than the pure application of cortical hormone in the treatment of systemic lupus erythematosus and it was worthy of clinical promotion and application.