组织蛋白酶与中药

Cathepsin and Chinese materia medica

组织蛋白酶来源于细胞内溶酶体,种类和功能多样,其在维持人体新陈代谢和疾病发生发展过程中表现出双重作用,其适度表达可促进组织或细胞的活化、增殖与代谢,对人体起到积极的作用,而过度表达又成为某些疾病发生发展的诱因,成为某种消极因素。中药作为传统医学重要的组成部分,来源广泛且副作用低,对组织蛋白酶的影响起着不可忽视的积极作用。目前,中药对于组织蛋白酶的相关研究起步较晚,并且发展缓慢。综述近年来国外关于组织蛋白酶的部分研究理论和国内关于中药在组织蛋白酶方面的研究内容,为中药干预治疗对组织蛋白酶诱发相关疾病研究提供部分参考。

Cathepsin, with various species and functions, derives from cell endolysosome. It has great impact on both sustaining eubolism and preventing diseases. Cathepsin has positive effect on human beings through its moderate expression to enhance the cells in their activation, multiplication, and metabolism. While its excessive expression might have a negative effect of inducing other diseases. Traditional Chinese herbs have been a crucial part of traditional Chinese medicine and they are various in species with less side effect, which has been paid close attention to. So far, researches about cathepsin become abundant among researchers home and abroad, while Chinese materia medica just takes up its gradual research not long before. This paper aims at briefly summarizing the latest academic researches on cathepsin home and abroad in terms of dependency structure, features of pathology and physiology as well as the intervention of traditional Chinese herbs to cathepsin in order to give a clear picture on its development.