丹参多酚酸盐注射液治疗慢性阻塞性肺疾病急性加重期的临床研究

Clinical study on Depsides Salts from Salvia miltiorrhiza in Lyophilizied Powder for injection in treatment of acute exacerbation of chronic obstructive pulmonary disease

目的观察注射用丹参多酚酸盐对慢性阻塞性肺疾病患者急性加重期的临床疗效。方法选取上海市嘉定区南翔医院2014年4月—2015年4月收治的慢性阻塞性肺病患者76例,随机分为对照组和治疗组,每组各38例。对照组患者给予常规治疗,治疗组患者在对照组治疗基础上加用注射用丹参多酚酸盐200 mg,溶于5%葡萄糖注射液250 m L中,静脉滴注,1次/d。两组患者均连续治疗14 d。评价两组患者治疗后的临床疗效,并比较两组治疗前后的各血清炎性因子水平和平均肺动脉压。结果治疗后,治疗组患者的总有效率为81.6%,显著高于对照组的70.1%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后两组血清白介素-18(IL-18)、C反应蛋白(CRP)水平均较治疗前显著降低,差异具有统计学意义(P<0.05);与对照组比较,治疗组血清IL-18、CRP水平降低程度均显著优于对照组(P<0.05)。治疗后两组肺动脉压水平均显著下降,差异具有统计学意义(P<0.05);且治疗组治疗后的下降程度明显高于对照组,差异具有统计学意义(P<0.05)。结论注射用丹参多酚酸盐治疗COPD急性加重期具有很好的临床疗效,可降低血清炎症因子IL-18和CRP水平以及平均肺动脉压,具有一定的临床推广应用价值。

Objective To observe the clinical effect of Depsides Salts from Salvia miltiorrhiza in Lyophilizied Powder for injection on the treatment of acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods Patients（76 cases） with acute exacerbation of COPD in Shanghai Jiading Nanxiang Hospital from April 2014 to April 2015 were randomly divided into control and treatment groups, and each group had 38 cases. The patients in the control group were given conventional treatment. The patients in the treatment group were iv administered with Depsides Salts from Salvia miltiorrhiza in Lyophilizied Powder for injection on the basis of the control group, 200 mg Depsides Salts from Salvia miltiorrhiza in Lyophilizied Powder for injection added into 5% Glucose Injection 250 m L, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical effects of two groups were evaluated. The levels of inflammatory factors and pulmonary arterial pressure of two groups before and after the treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 70.1% and 81.6%, respectively, and there were differences between two groups（P〈0.05）. After treatment, levels of IL-18 and CRP in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, pulmonary arterial pressures in two groups were obviously decreased, and the difference was statistically significant in the same group（P〈0.05）. These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Depsides Salts from Salvia miltiorrhiza in Lyophilizied Powder for injection has clinical curative effect in treatment of acute exacerbation of COPD, can decrease the levels of inflammatory factors IL-18 and CRP in serum and the average pulmonary arterial pressure, which has a certain clinical application value.