喷雾干燥工艺制备枸橼酸喷托维林微粉

Preparation of Superfine Pentoxyverine Citrate Powders by Spray Drying Process

采用喷雾干燥工艺制备枸橼酸喷托维林微粉,设计正交实验分析各工艺参数对微粉粒度分布的影响,优化工艺条件;利用X射线衍射与扫描电子显微镜表征微粉的微观结构和微观形貌,分析化合物的结晶过程。结果表明:枸橼酸喷托维林微粉最佳喷雾干燥工艺条件是料液中药物的质量浓度为0.03 g/m L,入口温度为170℃,进液速率为400 m L/h;喷雾干燥过程中,料液中悬浊颗粒物相结构不发生改变,微观形貌呈片状;溶质状态药物在固-液界面处晶态生长,或以非晶态析出,后者微观形貌主要为球形颗粒。

Superfine pentoxyverine citrate powders were prepared by spray drying process. Orthogonal experiments were designed to research the effect of technical parameters on particle size distribution and optimize the preparation process. Micro-structure and micro-morphology of the superfine powders were studied by XRD and SEM, and the process of crystallization was analyzed. The results show that the optimum process conditions for superfine pentoxyverine citrate powders are that the mass concentration in drug suspension is 0.03 g/m L, the input temperature is170 ℃, and the spray rate is 400 m L/h. During the spray drying process,the phase structure of previous pentoxyverine citrate of solid state does not change, and the particles exhibit flake shape. Part of solute remains the initial phase structure and crystallizes at liquid-solid interface, and the phase structure of others changes into amorphous state, micro-morphology of the later mainly presents spherical particles.