腹腔镜下卵巢打孔术联合二甲双胍治疗多囊卵巢综合征的临床分析

Clinical analysis of laparoscopic ovarian drilling combined with metformin in treatment of polycystic ovary syndrome

目的探讨腹腔镜下卵巢打孔术联合二甲双胍对多囊卵巢综合征(PCOS)的疗效价值。方法将2011年1月至2014年1月本院收治的80例PCOS患者按随机数字表法分为观察组和对照组,每组40例。观察组采用腹腔镜下卵巢打孔术(LOD)联合二甲双胍治疗,对照组采用氯米芬联合二甲双胍治疗。观察两组患者治疗前后黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)及雌二醇(E2)水平,并随访患者的月经周期、排卵和妊娠情况。结果观察组治疗后的LH、FSH、T及E2改善情况均优于对照组,差异有统计学意义(P<0.05)。在月经周期、排卵及妊娠方面比较,观察组也显著优于对照组(P<0.05)。结论腹腔镜下卵巢打孔术联合二甲双胍治疗多囊卵巢综合征疗效的满意,并能改善患者的生活质量,提高妊娠率。

Objective To observe the clinical effect of laparoscopic ovarian drilling combined with metformin in treatment of poly- cystic ovary syndrome（PCOS）. Methods Totally 80 patients with PCOS received in our hospital between January 2011 and Janu- ary 2014 were randomly divided into two groups. The observation group consisted of 40 patients were treated by ]aparoscopic ovarian drilling combined with mefformin, while the control group received elomiphene citrate combined with mefformin. The serum concen- tration of ]uteinizing hormone （ LH ）, follicle-stimulating hormone （ FSH ）, testosterone （T） and estradiol （ E2 ） were respectively com- pared before and after treatment. Menstruation cycle, ovulation rate and pregnancy rate were investigated and compared. Results Improvement of LH, FSH, T and E2 in observation group was significantly superior than in control group（ P 〈 0.05 ）. The menstrua- tion recover, ovulation rate and pregnancy rate of observation group was also significantly better than that of control group （ P 〈 0. 05 ）. Conclusion Laparoscopic ovarian drilling combined with mefformin is reliable and effective treatment of PCOS. It can in- crease pregnancy rate and improve living quality of patients.