肝硬化患者生化检测结果异常与疾病转归分析

Analysis on abnormal test results of biochemical studies and prognosis of disease in patients with liver cirrhosis

目的检测肝硬化患者血清生化和血细胞学指标,探讨异常结果在治疗、监测方面与疾病转归的关系。方法全自动生化分析仪检测生化项目,全自动血球分析仪检测血细胞学项目,全自动血凝仪检测血浆凝血酶原时间和凝血酶原活动度,对患者临床体征及症状进行咨询统计。结果与对照组比较,肝硬化患者血清酶活性、总胆汁酸、直接胆红素、凝血酶原时间、白蛋白、球蛋白和白细胞、血红蛋白、红细胞、血小板总数结果异常,差异显著(P<0.05或P<0.01),肝硬化患者固有的临床体征和症状表现突出。结论肝硬化患者血清生化和细胞学项目检测结果异常,反映了患者病情严重,是该病终末期的结局,且患者特有的体征和并发症出现是肝功能衰竭的标志。异常结果检出率越多,预后则不良。

Objective To investigate the relationship between abnormal results and prognosis of the liver cirrhosis in treatment and monitoring. Methods Full automatic biochemical analyzer were used to measure the biochemical genomics project,full automatic blood cell analyzer were employed to detect the hemocytology project,while full automatic blood coagulation analyzer were made to detect the original time and activity of plasma prothrombin,and clinical signs and symptoms of the patients were compared. Results Compared with the control group,the activity of plasma prothrombin,total bile acid,direct bilirubin,prothrombin time serum albumin,globulin and white blood cell,hemoglobin,red blood cell,platelet count in patients with liver cirrhosis were abnormal. The difference was significant（ P 0. 05 or P 0. 01）. The inherent clinical signs and symptoms of patients with liver cirrhosis were obvious. Conclusion The abnormal results of serum biochemistry and hemocytology in liver cirrhosis indicate that the patients are in critical condition. And the appearance of patients＇ specific signs and complications marks the hepatic failure. The more the abnormal results,the worse the prognosis.