新生儿PGC-1α基因Gly482Ser多态性与产妇妊娠期糖尿病的关系

ASSOCIATION BETWEEN THE NEONATAL PGC-1α GENE POLYMORPHISM AND THE PREGNANCY INDUCED GESTATIONAL DIABETES MELLITUS

目的：探讨新生儿过氧化物酶体增殖物激活受体γ辅助激活因子-1α（PGC-1α）基因Gly482Ser多态性与妊娠期糖尿病（GDM）的关系。方法：选取在我院住院的50例GDM产妇分娩的新生儿作为实验组以及50例正常产妇分娩的新生儿作为对照组,采用聚合酶链反应—限制性片段长度多态性（PCR-RFLP）技术,检测新生儿PGC-1α基因Gly482Ser多态性情况以及该多态性与产妇GDM的关系。结果：（1）实验组与对照组新生儿PGC-1α基因Gly482Ser多态性及等位基因的分布情况比较,差异无统计学意义（P〉0.05）。（2）分娩GG基因型或GA基因型新生儿的产妇患GDM的风险是分娩新生儿为AA基因型的产妇的3.20倍（95%CI=1.172~8.735）。结论：尚不能表明GDM产妇所分娩新生儿的PGC-1α基因Gly482Ser多态性与正常产妇分娩的新生儿有差异,但通过研究发现新生儿的PGC-1α基因型为AA可能是产妇患GDM的保护因素之一。

Objective:To investigate the relationship between the neonatal PGC-1αgene polymorphism and the pregnancy induced gestational diabetes mellitus(GDM).Methods:Fifty newborns of diabetic pregnant women and 50 controls from our hospital were recruited.PG1-1αgene polymorphism was detected by PCRRFLP to define the relationship between the neonatal PGC-1αgene polymorphism and GDM.Results:(1)There is no significant difference of the distribution of GG,GA and AA genotypes between the two groups(P >0.05).(2)It was discovered that mothers with newborns carrying the GG or AG had 3.2-fold higher risk of GDM than those with newborns carrying the AA genotype.Conclusion:There is on significant difference in allele distribution and Gly482 Ser genotype frequency between two groups.However,we discovered that AA genotype could be one of the protective factors of maternal GDM.