9p21染色体上rs4977574多态性与冠心病相关性研究

The association between rs4977574 polymorphism at chromosome 9p21 and coronary artery disease

目的 探讨rs4977574多态性与冠心病的关系.方法 运用实时定量PCR基因分型技术,对经冠状动脉造影证实的289例冠心病患者（冠心病组）和338例冠脉正常者（对照组）进行基因分型,并对两组基因型的关系进行分析比较.结果 两组间rs4977574多态的基因型分布差异有统计学意义（P〈0.05）,冠心病组CC型明显少于对照组（P〈0.01）.应用Logistic回归分析,CC型减少冠心病发病风险（ OR=0.71,95%CI=0.58-0.99,P〈0.05）.结论 rs4977574多态可能与冠心病发病相关,携带C等位基因者发生冠心病的风险降低.

Objective To investigate the association between rs4977574 polymorphism and coronary artery disease （CAD）.Methods 289 cases with CAD confirmed by angiography （CAD group） and 338 subjects with normal coronary artery （control group） were enrol ed.Genotyping was performed by real- time PCR and compared between the two groups.Results The genotype distribution of rs4977574 polymorphism differed significantly between CAD group and control group （P〈0.05）.CC type was fewer in CAD group than in control group.Logistic regression analysis showed that CC type reduced CAD risk （OR=0.71,95%Cl0.56~0.99,P〈0.05）.Conclusion There is an association between rs4977574 polymorphism and CAD.The population with C allele likely have a lower risk of CAD.