纳米银的血液相容性及作用机制研究进展

Recent progress on blood compatibility of silver nanoparticles and the related mechanisms

纳米银以其良好的抗菌性能被广泛用于食品工业、生物医药等诸多领域.但随着纳米银产品的不断发展与广泛使用,其生物安全性备受人们的重视.本文根据近年来国内外研究进展,全面总结纳米银接触人体进入到血液后引起的一系列血液生物效应(包括红细胞溶血、血小板聚集、白细胞增殖及其炎症反应、凝血级联反应和补体系统激活),并进一步分析总结了其可能的生物效应作用机制,以期能为纳米银的生物安全效应评估提供有效的参考,并对将来制备更高效且无毒的纳米银产品具有一定的指导意义.

Due to their excellent antimicrobial properties,silver nanoparticles（Ag NPs） have been extensively used for food industry,cosmetics,biomedicine and other application fields. Hence,the potential bio-safety of Ag NPs has already garnered more attention. According to the results of domestic and foreign research,this review attempts to summarize important progress of blood toxicities induced by Ag NPs,including hemolysis,platelet aggregation,leukocyte proliferation and inflammation,coagulation process and the activation of complement system during Ag NPs contacting with blood. Moreover,the possible toxic mechanism was also further generalized. This review would be helpful for a comprehensive bio-safety assessment of Ag NPs as a scientific guidance.