新诊断多囊卵巢综合征患者Nesfatin-1水平变化及相关因素研究

Changes of serum levels of nesfatin-1 in patients with newly-diagnosed polycystic ovary syndrome

目的探讨血清Nesfatin-1水平与多囊卵巢综合征(PCOS)的相关性。方法按PCOS的诊断标准选取61例患者为研究对象,分为超重组34例和正常体重组27例,并设健康女性为对照组。测定血清Nesfatin-1水平、空腹血糖(FBG)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T),计算体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR),并对各指标间的相关性进行分析。结果正常体重组PCOS患者与对照组比较,FINS、HOMA-IR、LH、LH/FSH及T升高,Nesfatin-1水平降低;超重组PCOS患者与对照组比较,BMI、WHR、收缩压、舒张压、FPG、FINS、HOMA-IR、TG、TC、LDL-C、LH、LH/FSH及T升高,HDL-C、Nesfatin-1水平降低;超重组PCOS患者与正常体重组患者比较,BMI、WHR、收缩压、舒张压、FPG、FINS、HOMA-IR、TG、TC、LDL-C、LH、LH/FSH及T升高,HDL-C降低,而Nesfatin-1水平仅有降低趋势。相关分析显示,血清Nesfatin-1与BMI、FINS、HOMA-IR、LH、T呈负相关;多元线性回归分析表明,HOMA-IR、LH、T是影响血清Nesfatin-1水平的重要因素。结论新诊断PCOS患者Nesfatin-1水平降低,Nesfatin-1可能参与PCOS的发生、发展。

[Objective] To investigate the change of serum nesfatin-1 in patients with newly-diagnosed polycystic ovary syndrome （PCOS）. [Methods] A total of 61 patients with PCOS were divided into two groups according to body mass index （BMI）： 34 cases in over-weight group （BMI ≥ 25 kg/m2, OW group） and 27 cases in normal-weight group （BMI 〈 25 kg/m2, NW group）. Healthy female subjects （30 cases） were included as controls. Serum level of nesfatin-1 was assayed by enzyme linked immunosorbent assay （ELISA）. Fasting plasma glucose （FPG）, fasting insulin （FINS）, triglyceride （TG）, total cholesterol （TC）, high-density lipoprotein （HDL）, low-density lipoprotein （LDL）, luteinizing hormone （LH）, follicle-stimulating hormone （FSH） and testos- terone （T） levels were also determined. Then BMI, waist-hip ratio （WHR） and HOMA-IR were calculated. [Results] Serum nesfatin-1 level in the PCOS patients was significantly lower than that in the controls （P〈 0.05）. The level of nesfatin-1 was negatively correlated with BMI, FINS, HOMA-IR, LH and T. Multiple lin- ear regression analysis showed that HOMA-IR, LH nesfatin-1. [Conclusions] Serum nesfatin-1 level in that in controls. Nesfatin-1 may play a role in the to be further studied. and T were the independent factors related to the serum newly-diagnosed PCOS patients is significantly lower than development of PCOS, but the specific mechanism needs