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心力衰竭治疗的新策略:血管紧张素受体脑啡肽酶双重抑制剂 被引量:4

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摘要 心力衰竭(心衰)是由于心脏结构或功能异常导致心室充盈或射血能力受损的一组复杂临床综合征.全世界约有2 300多万心衰患者,在我国35~74岁成年人中,心衰患者超过400万[1-2].据统计美国在过去40年中,由于心衰引起的死亡增加了6倍,并且发病率仍持续增加[3],可见心衰已经成为21世纪重要的公共卫生问题.
作者 刘萧 洪葵
机构地区 [
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2015年第12期1025-1027,共3页 Chinese Journal of Cardiology
基金 教育部创新团基金(IRT1141)
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参考文献23

  • 1Dunlay SM, Roger VL. Understanding the epidemic of heart failure: past, present, and future [ J ]. Curr Heart Fail Rep, 2014, 11(4) :404-415.
  • 2中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014,42(2):98-122. 被引量:4673
  • 3Packer M. Proposal for a new clinical end point to evaluate the efficacy of drugs and devices in the treatment of chronic heart failure[ J]. J Card Fail, 2001, 7(2) :176-182.
  • 4McMurray JJ, Adamopoules S, Anker SD, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC[J]. Eur Heart J, 2012, 33(14) : 1787-1847.
  • 5Jessup M. Neprilysin inhibition -a novel therapy for heart failure [J]. N Engl J Med, 2014, 371(11) :1062-1064.
  • 6McMurray JJ, Packer M, Desai AS, et al. Angiotensin-ueprilysin inhibition versus enalapril in heart failure [ J ]. N Engl J Med,2014, 371 ( 11 ) :993-1004.
  • 7von Lueder TG, Sangaralingham SJ, Wang BH, et al. Renin- angiotensin blockade combined with natriuretic peptide system augmentation: novel therapeutic concepts to combat heart failure [J]. Circ Heart Fail, 2013, 6(3) :594-605.
  • 8Sackner-Bernstein JD, Kowalski M, Fox M, et al. Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials [ J ]. JAMA, 2005, 293 ( 15 ) : 1900-1905.
  • 9O'Connor CM, Starling RC, Hernandez AF, et al. Effect of nesiritide in patients with acute decompensated heart failure[ J]. N Engl J Med, 2011, 365(1) :32-43.
  • 10von Lueder TG, Atar D, Krum H. Current role of neprilysin inhibitors in hypertension and heart failure [ J ]. Pharmacol Ther, 2014, 144(1) :41-49.

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