心脏再同步治疗心力衰竭的分子机制
摘要
心脏再同步化治疗(CRT)临床疗效已为大量研究所证实,CRT作用主要的分子机制如下:1恢复心肌细胞离子通道的表达,改善K^+通道、Na^+通道功能,抑制晚Na^+电流,缩短动作电位时程,减少早期后除极发作;2恢复β_1、β_2和增加、改善β_(AR);3恢复内质网Ca^(2+)循环;4CRT改善心肌细胞存活;5增加线粒体功能。
出处
《中国心脏起搏与心电生理杂志》
2015年第6期505-507,共3页
Chinese Journal of Cardiac Pacing and Electrophysiology
参考文献33
-
1Vanderheyden M, Mullens W, Delrue L, et al. Endomyocardial up- regulation of betal adrenoreceptor gene expression and myocardial contractile reserve following cardiac resynchronization therapy [ J ]. J Card Fail, 2008, 14(8) :172.
-
2Kaab S, Nuss HB, Chiamvimonvat N, et al. Ionic mechanism of ac- tion potential prolongation in ventricular myocytes from dogs with pa- cing-induced heart failure[J]. Circ Res,1996,78:262.
-
3Bennett PB, Yazawa K, Makita N, et al. Molecular mechanism foran inherited cardiac arrhythmia [ J ]. Nature, 1995,376:683.
-
4Aiba T, Barth AS, Hesketh GG, et al. Cardiac resynchronization therapy improves altered Na channel gating in canine model of dys- synchronous heart failure [ J ]. Circ Arrhythm Electrophysiol, 2013,6 (3) :564.
-
5Rengo G, Lymperopoulos A, Koch WJ. Future G protein-coupled receptor targets for treatment of heart failure[ J]. Curr Treat Options Cardiovasc Ned ,2009,11:328.
-
6Floras JS. The "unsympathetic" nervoussystem of heart failure[ J ]. Circulation ,2002,105 : 1 753.
-
7Chakir K, Daya SK, Tunin RS, et al. Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization [J]. Circulation, 2008, 117(3) :1 369.
-
8Chakir K, Daya SK, Aiba T, et al. Mechanisms of enhanced beta adrenergic reserve from cardiac resynchronization therapy [ J ]. Cir- culation, 2009, 119(8) :1 231.
-
9Chakir K, Depry C, Dimaano VL, et al. Galphas-biased beta2-ad- renergic receptor signaling from restoring synchronous contraction in the failing heart [ J ]. Sci Transl Med,2011,3:100ra88.
-
10Piacentino V 3rd, Weber CR, Chen X,et al. Cellular basis of ab- normal calcium transients of failing human ventricular myocytes [ J ]. Circ Res ,2003,92:651.
-
1楚英杰.伊布利特的心肌细胞离子通道的作用机制[J].临床心电学杂志,2008,17(1):6-7. 被引量：1
-
2王欢.膜片钳技术在心脏功能研究中的应用[J].国外医学（儿科学分册）,1997,24(6):281-284. 被引量：2
-
3黄鑫,李莉.钙调神经磷酸酶对心肌细胞离子通道的调节[J].中华心律失常学杂志,2006,10(6):450-452. 被引量：2
-
4朱萍,李玲玲,黄琴红,张萍.一例Brugada综合征患者的急救护理体会[J].中国急救复苏与灾害医学杂志,2009(7):538-538.
-
5万伟,周显顺,蔡红专.扩张型心肌病的离子通道发病机制研究进展[J].心血管病学进展,2012,33(4):551-553. 被引量：3
-
6王燕,邓秀玲.β_1亚单位酪氨酸过度磷酸化影响糖尿病大鼠BK_(Ca)通道功能[J].中国病理生理杂志,2010,26(A10):2061-2061.
-
7王秀红,张兆辉,苏凯.Brugada综合征的诊断及临床意义[J].中国煤炭工业医学杂志,2006,9(4):389-389.
-
8有田真,王绍坤.离子通道在室性心律失常发生上的意义——cAMP和Na^+电流[J].日本医学介绍,1989,10(7):302-302.
-
9李为东,蒋树中,付强,吴强,黄宜杰.长QT综合征和尖端扭转性室性心动过速的临床研究[J].上海医学,2007,30(S1):105-105. 被引量：2
-
10李喜涛,许文灿.连接蛋白43磷酸化状态与缝隙连接通道功能的关系[J].汕头大学医学院学报,2008,21(3):185-188. 被引量：1
