低强度脊髓神经刺激对心房电生理性质的影响

Effects of low-level spinal cord stimulation on atrial electrophysiological characters

目的研究低强度脊髓神经刺激（SCS）对心房电生理性质的影响。方法12只成年家犬随机分为SCS组（n=6）和对照组（n=6），以戊巴比妥钠麻醉，在左上肺静脉、右上肺静脉、左下肺静脉、右下肺静脉、左房、右房位点缝置多电极导管，SCS组在T1—T5脊髓节段放置刺激电极并给予SCS1h，对照组放置刺激导线但不给予刺激。分别在基础水平和1h后，心房基础起搏下，依次在心房和肺静脉各位点不应期内发放40ms的高频刺激测定心房颤动（简称房颤）阈值（AF—TH），用S1S2程序刺激法测定心房有效不应期（ERP）和房颤易颤窗口（WOV）。结果SCS组1h后与基础水平比较，心房和肺静脉各位点AF-TH增高，ERP延长，WOV减小（P均〈0．05）。SCS组1h后较对照组1h后AF—TH增高，ERP延长，WOV减小（P均〈0．05）。对照组基础水平与1h后各指标无变化。结论SCS可显著改变心房电生理性质，抑制房颤可诱导性。

Objective To investigate the effect of low-level spinal cord stimulation on atrial electrophysialogical characters. Methods Twelve pentobarbital anesthetized dogs were randomly divided into the SCS group （ n = 6） and the control group（n=6）. Catheters were sutured at multiple atrial and pulmonary vein sites. In 6 dogs of SCS group, SCS was delivered to to the spinal at T1-T5 level via wire electrodes. At baseline and 1 h of SCS, high frequency stimulation （HFS） was delivered 2 ms after atrial pacing to determine the AF threshold （AF-TH） at each site, and the effective refractory period （ERP） and window of vulnerability （WOV） for AF were also determined. Results 1 h of SCS induced a significant increase of AF-TH, prolongation of ERP and decrease of WOV. Conclusion SCS can significantly affect atrial electrophysiological characters and suppress AF inducibility. [ Chinese Journal of Cardiac Pacing and Electrophysiology,2015,29 （6） ：558-561]