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别嘌醇与慢性肾脏病的研究进展 被引量:2

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摘要 高尿酸血症(hyperuricemia,HUA)是慢性肾脏病(chronic kidney diseases,CKD)患者发生心血管事件、死亡的预测因素。别嘌醇(allopurinol)作为经典的抑制尿酸生成的药物,它除了降低尿酸可能还通过降低晚期糖基化终末产物(AGEs)的水平,阻止血管紧张素II的作用,可能具有延缓CKD的进展,减少CKD患者并发心血管事件的作用。
作者 李雪 刘建
出处 《中国中西医结合肾病杂志》 2015年第12期1109-1111,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
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  • 1Goicoechea M, Garcia DS, Verdalles UE, et al. Effect of allopuri- nol on chronic kidney diseaseprogression and cardiovascular risk. CLIN J Am SocNephrol,2010,5 (8) :1388 -1393.
  • 2Mehmet K, Bulent H,Alper A,et al. A Randomized Study of Al- lopurinol on Endothelial Function and Estimated Glomular Filtra- tion Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Function. The American Society of Nephrology, 2012,6 (6) :1887 - 1894.
  • 3Kaom P, Ang DS, Gandy SJ, et al. Allopurinol benefits left ven- tricular mass and endothelial dysfunction in chronic kidney dis- ease. Journal of the American Society of Nephrology, 2011,22 (7) :1382 - 1389.
  • 4Goicoechea M, Garcia DS, Verdalles U, et al. Allopurinol and Progression of CKD and Cardiovascular Events : Long - term Fol- low- up of a Randomized Clinical Trial. American Journal of Kidney Diseases : the Official ,2015 : 1 - 7.
  • 5Tsuruta Y, Nitta K, Akizawa T, et al. Association between allo- purinol and mortality among Japanese hemodialysis patients:re- suits from the DOPPS. International Urology and Nephrology, 2014,46(9) : 1833 - 1841.
  • 6Ng KP, Stringer S J, Jesky MD, et al. Allopurinol is an independ- ent determinant of improved arterial stiffness in chronic kidney disease : a cross - sectional study. PLOS ONE, 2014, 9 ( 3 ) : e91961.
  • 7Dogan A, Yarlioglues M, Kaya MG, et al. Effect of long term and high dose allopurinol therapy on endothelial function in normo-tensive diabetic patients. Blood Pressure, 2011,20 ( 3 ) : 182 - 187.
  • 8Talaat KM, El - sheikh AR. The effect of mild hyperuricemia on urinary transforming growth factor beta andthe progression of chronic kidney disease. Am J Nephrol,2007,27 (5) :435 -440.
  • 9Jia N, Dong P, Ye Y, et al. Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II - induced cardiac diastolic dysfunction. Cardiovascular Therapeutics,2012,30 (2) : 117 - 123.
  • 10Cheng CI, Tang Y, Zheng Z, et al. Advanced glycation end - products activate the renin - angiotensin system through the RAGE/PI3 - K signaling pathway in podocytes. Clinical and In- vestigatiw Medicine. Mdecine CLIN ,2012,35 (5) :E282.

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