期刊文献+

红花逍遥片对血虚风燥型特应性皮炎患者免疫因子影响的研究 被引量:4

下载PDF
导出
摘要 目的:观察红花逍遥片治疗血虚风燥型特应性皮炎(AD)的临床效果及对患者血液中免疫因子水平的影响。方法:85例血虚风燥型AD患者随机分为治疗组和对照组,两组均采用甘草润肤洗剂外用治疗,治疗组43例加用红花逍遥片治疗,对照组42例加用氯雷他定颗粒治疗。应用ELISA法检测两组血清TNF-a、IL-17A、IL-23、TGF-β1水平;应用q RT-PCR方法检测外周血浆趋化因子MDC/CCL22、TARC/CCL17、CTACK/CCL27、RANTES/CCL5和CXCL10/IP-10 m RNA的表达。结果:6周后治疗组临床基本治愈26例,显效10例,好转5例,无效2例,总有效率83.7%,对照组临床基本治愈5例,显效19例,好转10例,无效8例,总有效率为57.1%,两组相比差异具有显著性意义(u=4.1731)。治疗组治疗前血清IL-17A为(68.32±13.47)pg/ml,治疗后为(20.56±15.51)pg/ml,其表达水平下调明显,且与CXCL10/IP-10分子呈正直线相关(r=0.5218,P<0.05);IL-23、TARC/CCL17治疗后表达水平明显下调,但与IL-17A及CXCL10/IP-10无明显相关性;而TNF-a、TGF-β1和其他趋化因子治疗前后变化不明显。结论:红花逍遥片联合甘草润肤洗剂可以负向调控CXCL10/IP-10和IL-17A的表达从而影响表皮角化过程,这可能在其对特应性皮炎患者的治疗中起重要作用。
出处 《实用中西医结合临床》 2015年第10期10-13,共4页 Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
基金 国家自然科学基金项目(编号:81360599) 广西自然科学基金项目(编号:2013GXNSFAA019148) 广西壮族自治区卫生厅课题(编号:GZZY13-17)
  • 相关文献

参考文献11

  • 1黄玉贝,张华敏,刘松林.名老中医苏忠德丹栀逍遥散治疗湿疹的经验[J].光明中医,2010,25(6):943-943. 被引量:5
  • 2钟江,付兰兰,方刚,林辰,覃永健,张衍.甘草润肤洗剂合多磺酸粘多糖乳膏治疗手部角化性湿疹50例临床研究[J].浙江中医杂志,2010,45(9):635-636. 被引量:3
  • 3Werfel T.The role of leukocytes,keratinocytes,and allergen-specific Ig E in the development of atopic dermatitis[J].J Invest Dermatol,2009,129(8):1878-1891.
  • 4Palmer CN,Irvine AD,Terron-KWiatkows-ki A,et al.Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis[J].Nat Genet,2006,38(4):441-446.
  • 5Kaplan AP.Chemokines,chemokine receptors and allergy[J].Int Arch Allergy Immunol,2001,124(4):423-43.
  • 6Riis JL,Johansen C,Vestergaard C,et al.Kinetics and differential expression of the skin-related chemokines CCL27 and CCL17 in psoriasis,atopic dermatitis and allergic contact dermatitis[J].Exp Dermatol,2011,20(10):789-794.
  • 7Nakazato J,Kishida M,Kuroiwa R,et al.Serum levels of Th2chemokines,CCL17,CCL22,and CCL27,were the important markers of severity in infantile atopic dermatitis[J].Pediatr Allergy Immunol,2008,19(7):605-613.
  • 8Baars EW,Nierop AF,Savelkoul HF.Development of systems biology-oriented biomarkers by permuted stepwise regression for the monitoring of seasonal allergic rhinitis treatment effects[J].J Immunol Methods,2012,378(1-2):62-71.
  • 9Bajoriuniene I,Malakauskas K,Lavinskiene S,et al.Response of peripheral blood Th17 cells to inhaled Dermatophagoides pteronyssinus in patients with allergic rhinitis and asthma[J].Lung,2012,190(5):487-495.
  • 10Santibaez JF,Quintanilla M,Bernabeu C.TGF-β/TGF-βreceptor system and its role in physiological and pathological conditions[J].Clin Sci(Lond),2011,121(6):233-251.

二级参考文献1

  • 1刘辅仁.实用皮肤病学[M].第3版.北京:人民卫生出版社,2005:419.

共引文献6

同被引文献63

  • 1崔晗,姚春海,宋艳丽,佘远遥,郎娜,陈少君,张天博,王晶晶.基于知识图谱中医药诊治特应性皮炎现状分析[J].辽宁中医杂志,2022,49(7):5-8. 被引量:5
  • 2吴泰相,刘关键,李静.影响系统评价质量的主要因素浅析[J].中国循证医学杂志,2005,5(1):51-58. 被引量:50
  • 3姚守恩,周渐云.许铣治疗异位性皮炎经验[J].实用中医药杂志,2006,22(2):116-116. 被引量:6
  • 4郎娜,姚春海,柏燕军,迟慧彦,佘远遥,黄尧洲.参归煎剂合湿毒膏治疗血虚风燥型特应性皮炎[J].中国中西医结合皮肤性病学杂志,2007,6(1):22-23. 被引量:5
  • 5Shaker M.New insights into the allergic march[J].Curr Opini Orthopaed,2014,26(4):516-520.
  • 6Odhiambo JA,Williams HC,Clayton TO,et al.Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three[J].J Aller Clin Immunol,2009,124(6):1251-1258.
  • 7Guttman-Yassky E,Nograles KE,Krueger JG.Contrasting pathogenesis of atopic dermatitis and psoriasis-Part I:Clinical and pathologic concepts[J].J Aller Clin Immunol,2011,127(5):1110-1118.
  • 8Gittler JK,Shemer A,Suárez-Farias M,et al.Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis[J].J Aller Clin Immunol,2012,130(6):1344-1354.
  • 9Baker BS.The role of microorganisms in atopic dermatitis[J].Clin Experim Immunol,2006,144(1):1-9.
  • 10Boguniewicz M,Leung DY.Atopic dermatitis:A disease of altered skin barrier and immune dysregulation[J].Immunol Rev,2011,242(1):233-246.

引证文献4

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部