76例HIV阳性孕产妇抗病毒治疗预防母婴传播效果分析

Study on the Effect of 76 HIV-infected Pregnant Women with Antiviral Treatment in Prevention from Mother-to-child Transmission

目的分析贺州市艾滋病病毒(HIV)阳性孕产妇,采用抗病毒治疗(ART)等干预措施预防母婴传播的效果。方法采用回顾性分析方法,对贺州市人民医院2007-2010年收治的HIV阳性孕产妇进行ART、产程干预、人工喂养等干预措施,观察新生儿的体重、身长和阿普加评分,追踪随访新生儿至18月龄,18个月时检测HIV抗体。结果共观察HIV阳性孕产妇76例。76名新生儿平均身长(49.54±1.70)cm,平均体重(2.86±0.36)kg,阿普加评分(9.86±0.58)分,均低于世界卫生组织的新生儿标准。孕产妇抗病毒治疗时间平均为29周,其中47.37%(36/76)达到全程治疗,所生儿童随访至18个月时HIV抗体检测均阴性。结论贺州市HIV阳性孕妇经过抗病毒治疗等干预措施可以明显预防HIV母婴传播,值得大力推广。

Objective To analyze the effect of antiviral treatment in prevention from mother-to-child transmission of HIV/AIDS in Hezhou City.Methods Retrospective analysis was used to follow up the 76 cases of HIV-infected pregnant women with HAART from 2007 to 2010,during which the women were intervened in the stage of labor,and artificial feeding,and the newborns＇ weight,height,apgar score and HIV-Ab were recorded until 18 months.Results All the infants followed up to 18 months were negative HIV antibody.The average height and weight of the newborns was 49.54±1.70 cm,and 2.86±0.36 kg respectively,with the apgar score 9.86±0.58,which were below the baby growth standards of WHO.The average treatment time of pregnant women was 29 weeks,with 47.37%（36/76）of them receiving HAART throughout the course of their pregnancy and production.Conclusion HAART can be effective to prevent from HIV motherto-child transmission.