妊娠合并甲状腺功能减退和亚临床甲状腺功能减退与新生儿甲减的关系

Combined with hypothyroidism and subclinical thyroid function in pregnancy and neonatal hypothyroidism

目的探讨妊娠合并甲状腺功能退减和亚临床甲状腺功能减退与新生儿甲减患病率的影响。方法回顾性分析2007年1月—2014年1月在我院住院的妊娠合并甲状腺功能减退69例,妊娠合并亚临床甲状腺功能减退123例,分析药物治疗妊娠合并甲减和亚临床甲减以及孕期甲功达标与否对新生儿甲状腺功能减退患病率的影响。结果药物治疗组新生儿甲减的患病率较非药物组新生儿甲减患病率明显下降(P<0.05)。药物治疗亚临床甲减与临床甲减的孕妇其新生儿患病率无差别(P>0.05)。孕期TSH达标的孕妇其新生儿患病率减少(P<0.05)。结论对于妊娠合并甲状腺功能减退或亚临床甲状腺功能减退的患者,均需要药物的治疗,并且在整个孕期中,我们尽可能使TSH达标,这样就能减少或消除新生儿甲状腺功能减退症的患病率,从而达到优生优育的效果。

Objective： To study the thyroid function in pregnancy with diminished and subclinical hypothyroidism and neonatal hypothyroidism prevalence rate. Methods： retrospective analysis of January 2007 to January 2014 in our hospital 69 cases of pregnancy complicated hypothyroidism, subclinical hypothyroidism during pregnancy in 123 cases, analysis of drug therapy combined with hypothyroidism and subclinical hypothyroidism and thyroid function during pregnancy, standard or not on neonatal hypothyroidism prevalence rate of pregnancy. Results： the treatment group of neonatal hypothyroidism prevalence than without treatment of group neonatal hypothyroidism prevalence rate significantly decreased （P〈0.05） . Drug treatment of subclinical hypothyroidism and subclinical hypothyroidism pregnant women, her newborn prevalence rate is not difference （P〉0.05） . pregnant women Monitore TSH level during pregnancy and let it up to the standard, her newborn prevalence rate decreased （P〈0.05） . Conclusion： for the patients with pregnancy complicated hypothyroidism or subclinical hypothyroidism, require drug therapy, and throughout pregnancy, we as far as possible to make the TSH up to standard, so it can reduce or eliminate the morbidity rate of neonatal hypothyroidism patients, so as to achieve the effect of prenatal and postnatal care.